Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa
Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa
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DOI：
10.1111/aos.12693
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发表时间：
2015-12-01
影响因子：
3.4
通讯作者：
Ishibashi, Tatsuro
中科院分区：
文献类型：
--
作者：
Murakami, Yusuke;Ikeda, Yasuhiro;Ishibashi, Tatsuro
目的：目的：探讨视网膜色素变性（retinitis pigmentosa，RP）患者黄斑区血流的变化及其与中心视功能的关系。方法：采用激光散斑血流图（Laser speckle flow graphy，简称MBR）测量视网膜和脉络膜血流的平均模糊率（mean blur rate，简称MBR）。在黄斑区的平均模糊率值进行了比较，70例RP和28名对照组。MBR之间的关系，一方面，另一方面，视力（VA），平均偏差（MD）和平均黄斑敏感度的静态视野检查（汉弗莱现场分析仪，中央10-2程序）与RP患者进行了分析。结果：黄斑MBR与RP患者相比，对照组下降至75%（p < 0.0001，学生t检验）。斯皮尔曼秩和检验显示黄斑MBR与视力显著相关（r =-0.261，p = 0.0299），MD值（r = 0.438，p = 0.0002）和静态视野检查中心4点和12点的平均黄斑敏感度（r分别为0.426和0.442，p = 0.0003和0.0002）。多变量校正分析证实，MBR与MD（p = 0.0002）和黄斑中心4点和12点敏感度（p分别< 0.0001和0.0002）独立相关。虽然因果关系仍有待阐明，这些研究结果表明，血管缺陷可能参与RP的发病机制，如中心视力丧失。
Purpose: To investigate the changes in macular blood flow and the correlation between those changes and central visual function in patients with retinitis pigmentosa (RP).Methods: The mean blur rate (MBR), a quantitative blurring index of the laser speckle pattern that represents retinal and choroidal blood flow, was measured by laser speckle flowgraphy. Mean blur rate values in the macular area were compared between 70 patients with RP and 28 control subjects. The relationships between MBR on the one hand and, on the other, visual acuity (VA), mean deviation (MD) and averaged macular sensitivity of static perimetry tests (Humphrey Filed Analyzer, the central 10-2 program) were analysed in patients with RP.Results: Macular MBR was decreased to 75% in patients with RP compared with control subjects (p < 0.0001, Student's t-test). Spearman's rank testing showed that macular MBR was significantly correlated with VA (r = -0.261, p = 0.0299), MD values (r = 0.438, p = 0.0002) and averaged macular sensitivity at the central 4 and 12 points of static perimetry tests (r = 0.426 and 0.442, p = 0.0003 and 0.0002, respectively). Multivariable-adjusted analysis confirmed that MBR was independently associated with MD (p = 0.0002) and macular sensitivity at the central 4 and 12 points (p < 0.0001 and 0.0002, respectively).Conclusions: Decreased macular blood flow was associated with reduced macular visual sensitivity in patients with RP. Although the cause-effect relationships remain to be elucidated, these findings suggest that vascular defects may be involved in the pathogenesis of RP such as central vision loss.