The high expression of FOXA1 is correlated with a favourable prognosis in salivary duct carcinomas: a study of 142 cases
The high expression of FOXA1 is correlated with a favourable prognosis in salivary duct carcinomas: a study of 142 cases
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DOI：
10.1111/his.13706
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发表时间：
2018-09
期刊：
影响因子：
6.4
通讯作者：
M. Urano;H. Hirai;Y. Tada;D. Kawakita;Tomotaka Shimura;K. Tsukahara;S. Kano;Hiroyuki Ozawa;K. Ok
中科院分区：
文献类型：
--
作者：
M. Urano;H. Hirai;Y. Tada;D. Kawakita;Tomotaka Shimura;K. Tsukahara;S. Kano;Hiroyuki Ozawa;K. Ok
涎腺导管癌（SDC）是一种罕见的侵袭性肿瘤，在组织学上类似于高级别乳腺导管癌，其特征在于雄激素受体（AR）的表达。雄激素信号通路是一个潜在的治疗靶点，可由FOXA 1调节。本研究旨在探讨FOXA 1在SDC中的临床病理意义。
Salivary duct carcinoma (SDC) is an uncommon, aggressive tumour that, histologically, resembles high‐grade mammary ductal carcinoma, and is characterised by the expression of androgen receptor (AR). The androgen signalling pathway, a potential therapeutic target, can be regulated by FOXA1. This study aimed to evaluate the clinicopathological implications of FOXA1 in SDC.