The design and synthesis of a novel chiral 1,1 '-disubsitituted ruthenocenyl phosphine-oxazoline ligand
The design and synthesis of a novel chiral 1,1 '-disubsitituted ruthenocenyl phosphine-oxazoline ligand
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DOI：
10.1007/s11164-020-04253-1
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发表时间：
2020
影响因子：
3.3
通讯作者：
Zhang Wanbin
中科院分区：
文献类型：
--
作者：
Ye Jianxun;Xu Yunnan;Li Jingjing;Liu Delong;Zhang Wanbin
手性二茂铁基膦-恶唑啉配体在不对称催化中表现出高效的不对称催化行为；然而，相应的手性钌茂化合物的设计和合成尚未得到广泛探索。在本文中，我们报告了基于精心设计和实验探索的手性二茂钌基 1,1'-膦-恶唑啉配体的合成。实验结果再次表明1,1'-二取代手性钌烯基配体的合成制备与相应的二茂铁不同。该方法为1,1'-二取代钌茂基配体的合成提供了可行且实用的策略。
Chiral ferrocene-based phosphine–oxazoline ligands have shown efficient asymmetric catalytic behaviors in asymmetric catalysis; however, the design and synthesis of the corresponding chiral ruthenocenes have not been widely explored. In this article, we report the synthesis of a chiral ruthenocene-based 1,1′-phosphine–oxazoline ligand, based on careful design and experimental exploration. The experimental results here reveal again that the synthetic preparation of 1,1′-disubstituted chiral ruthenocenyl ligands differs from the corresponding ferrocenes. The current method provides a feasible and practical strategy for the synthesis of 1,1′-disubstituted ruthenocene-based ligands.