Chronic myelocytic leukemia probably promoted by growth hormone.
Chronic myelocytic leukemia probably promoted by growth hormone.
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慢性粒细胞白血病可能是由生长激素促进的。
DOI：
10.1620/tjem.158.263
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
T. Konno
中科院分区：
文献类型：
--
作者：
A. Ishii;K. Kakuta;S. Tsuchiya;T. Konno
该研究显示临床证据表明，生长激素 (GH) 可能会促进一名 14 岁男孩罹患 Ph1 阳性慢性粒细胞白血病，该男孩因颅咽管瘤手术和放射治疗后生长障碍而接受 GH 治疗。 GH治疗一年后出现与未成熟粒细胞相关的白细胞增多和白细胞碱性磷酸酶评分低。细胞遗传学研究表明存在 Ph1 染色体。
The study shows clinical evidence that growth hormone (GH) presumably promoted Ph1-positive chronic myelocytic leukemia in a 14-year-old boy who was receiving GH treatment for growth failure after surgery and irradiation for craniopharyngioma. Leukocytosis associated with immature myelocytic cells and low leukocyte alkaline phosphatase score appeared one year after GH treatment. Cytogenic study showed the presence of Ph1 chromosome.