Cognitive functions and psychopathological symptoms in early-onset schizophrenia
Cognitive functions and psychopathological symptoms in early-onset schizophrenia
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DOI：
10.1007/s007870050111
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发表时间：
2000-03-01
影响因子：
6.4
通讯作者：
Remschmidt, H
中科院分区：
文献类型：
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作者：
Banaschewski, T;Schulz, E;Remschmidt, H
以74名主要患有慢性精神分裂症的青少年为样本，研究了客观测试的认知障碍（注意力、语言流畅性、非语言推理）的类型和程度及其与精神病理症状的自我评定（偏执抑郁量表；法兰克福投诉问卷）和临床评定（简短精神病学评定量表，阳性和阴性症状评定量表）的关系。平均病程= 3.4年)，包括15例极早发病（< 14年）。对阳性和阴性症状的区分给予了特别考虑。在横断面分析中，精神分裂症青少年在认知功能（注意力、推理）和精神病理测量（BPRS、SANS、SAPS）方面都明显受损。然而，因子分析得出认知和精神病理参数的正交因子，典型相关分析没有发现这两个领域之间的显著相关性。由于慢性精神分裂症青少年客观测量的认知障碍程度不能通过个体精神病理症状的严重程度来预测，因此对症状学进行多维评估似乎是合适的。此外，还研究了病前障碍（运动和/或语言发育障碍）和发病特征（年龄、模式、亚诊断）及其与认知障碍的关系。病前障碍被证实为随后发生认知障碍的危险因素。
Type and extent of objectively tested cognitive impairments (attention, verbal fluency, nonverbal reasoning) and their association with self-ratings (Paranoia Depression Scale; Frankfurt Complaint Questionnaire) and clinical assessments (Brief Psychiatric Rating Scale, Scales for the Assessment of Positive Symptoms and Negative Symptoms) of psychopathological symptoms were studied in a sample of 74 adolescents primarily suffering from chronic schizophrenia (DSM-III-R; mean duration of illness = 3.4 years), including 15 patients with a very early onset (< 14 years). Special consideration was given to the differentiation between positive and negative symptoms. In cross-sectional analyses, the schizophrenic adolescents were remarkably impaired in both cognitive functions (attention, reasoning) and psychopathological measures (BPRS, SANS, SAPS). However, factor analysis yielded orthogonal factors for cognitive and psychopathological parameters, and canonical correlation analyses did not find a significant correlation between these two areas. As the degree of objectively measured cognitive impairment in chronic schizophrenic adolescents cannot be predicted by the severity of individual psychopathological symptoms, a multidimensional evaluation of the symptomatology seems to be appropriate. Moreover, premorbid disturbances (motor and/or language developmental disorders) and onset characteristics (age, pattern, subdiagnosis), and their relationship to cognitive impairments were investigated. Premorbid disturbances were confirmed as risk factors for the subsequent occurrence of cognitive impairments.