Oxidative Stress Correlates with Complications Among Diabetic Patients Attending a Diabetic Clinic in Muhimbili National Hospital, Dar es Salaam, Tanzania
Oxidative Stress Correlates with Complications Among Diabetic Patients Attending a Diabetic Clinic in Muhimbili National Hospital, Dar es Salaam, Tanzania
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DOI：
10.1007/s12291-012-0276-x
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发表时间：
2013-04-01
影响因子：
2.1
通讯作者：
Lutale, Janne
中科院分区：
文献类型：
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作者：
Genet, Solomon;Lema, Yakobo;Lutale, Janne
在糖尿病中，持续的高血糖会导致自由基的产生增加，特别是氧自由基，这可能会导致细胞破坏和组织损伤，导致细胞功能障碍。在氧化应激是糖尿病并发症的主要原因的前提下，我们对住在Muhimbili国立医院的1型和2型糖尿病患者的血清过氧化脂质水平进行了对照实验室调查。从我们的临床资料中观察到，大多数患者的腰臀比和体重指数较高，这表明患者要么超重，要么肥胖。入选的糖尿病患者的过氧化脂质水平高于对照组，2型患者的过氧化脂质水平也高于1型患者。此外，有已知并发症的患者比没有并发症的患者有更高的过氧化脂质水平。糖尿病患者的过氧化脂质水平与参加研究的对照组有显著差异。大多数糖尿病患者的血糖控制不佳。我们的发现提示，尽管我们诊所的糖尿病患者正在进行随访，但他们存在发展为冠心病、神经病变和其他继发性糖尿病并发症的风险。
In diabetes, persistent hyperglycemia results in increased production of free radicals especially oxygen free radicals, which can cause cell destruction and tissue injury resulting in cell dysfunction. With the premise that oxidative stress is a major cause of diabetic complications, we conducted a controlled laboratory based investigation on level of lipid peroxide levels in the serum of Type 1 and Type 2 diabetic patients attending Muhimbili National Hospital. From our clinical data it was observed that majority of the patients had higher waist to hip ration and body mass index, which suggests that the patients were either overweight or obese. The enrolled diabetic patients had higher lipid peroxide levels than controls and also Type 2 patients had higher lipid peroxide levels than Type 1 patients. Moreover, patients with known complications had higher lipid peroxide levels than patients without complications. The lipid peroxide levels in the diabetic patients were significantly different from that of the control subjects enrolled in the study. A majority of the diabetic patients had a poorly controlled blood sugar. Our finding hints that despite the fact that diabetic patients in our clinic are on follow up, they are at a risk of developing coronary heart diseases, neuropathy and other secondary diabetic complications.