Comparative Analysis of African Swine Fever Virus Genotypes and Serogroups
Comparative Analysis of African Swine Fever Virus Genotypes and Serogroups
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DOI：
10.3201/eid2102.140649
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发表时间：
2015-02-01
影响因子：
11.8
通讯作者：
Kolbasov, Denis
中科院分区：
文献类型：
--
作者：
Malogolovkin, Alexander;Burmakina, Galina;Kolbasov, Denis
非洲猪瘟病毒（ASFV）在猪中引起高度致命的出血性疾病，ASFV的极端抗原多样性阻碍了疫苗的开发。我们发现p72 ASFV系统发育分析不能准确定义ASFV血液吸附抑制试验血清群。因此，传统的ASFV基因分型不能区分不同毒力的病毒或预测特定ASFV疫苗的效力。
African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV's extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition assay serogroups. Thus, conventional ASFV genotyping cannot discriminate between viruses of different virulence or predict efficacy of a specific ASFV vaccine.