Dehydroepiandrosterone sulfate: A biomarker of primate aging slowed by calorie restriction
Dehydroepiandrosterone sulfate: A biomarker of primate aging slowed by calorie restriction
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DOI：
10.1210/jc.82.7.2093
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发表时间：
1997-07-01
影响因子：
5.8
通讯作者：
Roth, GS
中科院分区：
文献类型：
--
作者：
Lane, MA;Ingram, DK;Roth, GS
肾上腺类固醇脱氢表雄酮（DHEA）及其硫酸盐（DHEAS）因其可能的抗衰老作用而引起人们的关注。人体中的 DHEAS 水平随着年龄的增长而显着下降，这表明该参数作为衰老生物标志物的潜在重要性。在这里，我们报告说，正如在人类中所见，雄性和雌性恒河猴的血清 DHEAS 表现出与年龄相关的稳定下降。这种下降符合衰老生物标志物的几个标准，包括随年龄的横截面和纵向线性下降以及个体差异随时间的显着稳定性。此外，恒河猴中与年龄相关的 DHEAS 损失比例是人类中观察到的下降速度的两倍多。最重要的是，我们发现，在恒河猴中，热量限制可以延长实验室啮齿类动物的寿命并延缓衰老，从而减缓成熟后血清 DHEAS 水平的下降。这是第一个证据表明这种营养干预有可能改变长寿物种的成熟后衰老的各个方面。
The adrenal steroids, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), have attracted attention for their possible antiaging effects. DHEAS levels in humans decline markedly with age, suggesting the potential importance of this parameter as a biomarker of aging. Here we report that, as seen in humans, male and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. This decline meets several criteria for a biomarker of aging, including cross-sectional and longitudinal linear decreases with age and significant stability of individual differences over time. In addition, the proportional age-related loss of DHEAS in rhesus monkeys is over twice the rate of decline observed in humans. Most important is the finding that, in rhesus monkeys, calorie restriction, which extends life span and retards aging in laboratory rodents, slows the postmaturational decline in serum DHEAS levels. This represents the first evidence that this nutritional intervention has the potential to alter aspects of postmaturational aging in a long-lived species.