Long-distance propagation of forces in a cell
Long-distance propagation of forces in a cell
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DOI：
10.1016/j.bbrc.2005.01.070
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发表时间：
2005-03-25
影响因子：
3.1
通讯作者：
Suo, ZG
中科院分区：
文献类型：
--
作者：
Wang, N;Suo, ZG
在力学传导领域的一个基本问题是力如何在细胞内传播。最近的实验表明，通过粘着斑施加的生理量级的力可以传播到细胞中很长的距离。这一观察结果与将细胞视为同质体的现有模型不一致。我们表明，这种“行动在一个距离”的结果从细胞中的不均匀性：一个预应力和僵硬的肌动蛋白束guicics的传播力在很长的距离。我们的模型突出了巨大的比例的预应力和模量的肌动蛋白束的模量的细胞骨架网络。对于正常细胞，模型预测力在与细胞大小相当的特征长度上传播。然而，特征长度可以通过处理细胞来改变。我们提供了实验证据，并讨论了生物学意义。(C)2005年爱思唯尔公司All rights reserved.
A fundamental question in the field of mechanotransduction is how forces propagate inside a cell. Recent experiments have shown that a force of a physiological magnitude, applied via a focal adhesion, can propagate a long distance into the cell. This observation disagrees with existing models that regard the cell as a homogeneous body. We show that this "action at a distance" results from the inhomogeneity in the cell: a prestressed and stiff actin bundle guicics the propagation of forces over long distances. Our models highlight the enormous ratios of the prestress and the modulus of the actin bundle to the modulus of the cytoskeleton network. For a normal cell, the models predict that forces propagate over characteristic lengths comparable to the size of the cell. The characteristic lengths can be altered, however, by treatments of the cell. We provide experimental evidence and discuss biological implications. (C) 2005 Elsevier Inc. All rights reserved.