Estimation of cross-ancestry genetic correlations within ancestry tracts of admixed samples.
Estimation of cross-ancestry genetic correlations within ancestry tracts of admixed samples.
复制标题
混合样本祖先区域内跨祖先遗传相关性的估计。
DOI：
10.1038/s41588-023-01325-x
复制
发表时间：
2023
期刊：
影响因子：
30.8
通讯作者：
Atkinson,ElizabethG
中科院分区：
文献类型：
--
作者：
Atkinson,ElizabethG
量化不同人群是否具有相似的常见因果变异效应大小对于了解疾病的遗传基础和建立更好的预测模型至关重要。一项新的研究提出了一种利用混合来估计因果遗传变异相关性的方法，并发现它们在不同的祖先背景中基本上相似。
Quantifying whether different populations share similar effect sizes of common causal variants is vital to understand the genetic basis of disease and build better prediction models. A new study proposes a method leveraging admixture to estimate the correlation of causal genetic variants and finds they are largely similar across ancestry backgrounds.