Interactions between enteropathogenic Escherichia coli and host epithelial cells
Interactions between enteropathogenic Escherichia coli and host epithelial cells
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DOI：
10.1016/s0966-842x(97)01000-7
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发表时间：
1997-03-01
影响因子：
15.9
通讯作者：
Finlay, BB
中科院分区：
文献类型：
--
作者：
Donnenberg, MS;Kaper, JB;Finlay, BB
肠致病性大肠杆菌（EPEC）感染的发病机制正在成为一个多阶段的微生物-宿主细胞相互作用的范例。IV型菌毛和III型分泌器在细菌和宿主细胞之间的相互作用中起主要作用。最近的数据表明，细菌诱导的信号转导激活了受体，使细菌能够牢固地粘附在宿主细胞表面。
The pathogenesis of enteropathogenic Escherichia coli (EPEC) infection is emerging as a paradigm for a multistage microorganism-host cell interaction. Both type IV fimbriae and a type III secretion apparatus play principal roles in interactions between the bacteria and host cells. Recent data suggest that bacteria-induced signal transduction activates the receptor that allows tenacious adherence of the bacteria to the host cell surface.