Spontaneous recovery of tolerance to the analgesic effect of morphine.
Spontaneous recovery of tolerance to the analgesic effect of morphine.
复制标题
对吗啡镇痛作用的耐受性自发恢复。
DOI：
10.1016/s0031-9384(02)00651-0
复制
发表时间：
2002
影响因子：
2.9
通讯作者：
Riccio,DavidC
中科院分区：
文献类型：
--
作者：
Millin,PaulaM;Riccio,DavidC
现在有大量证据表明，联想过程有助于麻醉耐受性的发展和表达。像其他条件反应一样，被认为介导耐受性的代偿反应（CR）可以通过反复单独呈现条件刺激（CS，药物配对上下文线索）而被消除。在本实验中，大鼠被用来确定在最后一次灭绝试验和再次暴露于CS之间的足够延迟后，吗啡镇痛作用的条件耐受性是否会自发恢复。结果发现，在9次灭绝试验的最后一次试验后72小时，耐受性自发恢复，但不是24小时。除了为麻醉品耐受的巴甫洛夫模型提供支持外，这一发现对提示暴露药物和酒精康复策略具有重要的临床意义。
There is now substantial evidence that associative processes contribute to the development and expression of narcotic tolerance. Like other conditioned responses, the compensatory response (CR) thought to mediate tolerance can be extinguished by repeatedly presenting the conditioned stimulus (CS, drug-paired contextual cues) alone. In the present experiments, rats were used to determine if conditioned tolerance to the analgesic effect of morphine would spontaneously recover following a sufficient delay between the last extinction trial and reexposure to the CS. It was found that tolerance spontaneously recovered 72, but not 24 h following the last of nine extinction trials. As well as providing support for a Pavlovian model of narcotic tolerance, this finding has important clinical implications for cue-exposure drug and alcohol rehabilitation strategies.