Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus
Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus
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DOI：
10.1111/joim.12903
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发表时间：
2019-08-01
影响因子：
11.1
通讯作者：
Prasad, R. B.
中科院分区：
文献类型：
--
作者：
Arora, G. P.;Akerlund, M.;Prasad, R. B.
目的妊娠期糖尿病（GDM）是妊娠期胰岛素分泌和作用受损的一种一过性糖尿病。存在基于人群的患病率差异，这可以用表型和遗传差异来解释。本研究的目的是检查这些差异孕妇从旁遮普，印度和斯堪的纳维亚半岛。方法根据瑞典GDM标准，在4018名旁遮普印度人和507名瑞典孕妇中，对来自先前研究的欧洲和/或印度人群中的85个GDM/T2 D位点与GDM的相关性进行评估。在斯堪的纳维亚队列、Radiel（N = 398，芬兰人）和STORK/STORK-G（N = 780，挪威人）中复制选定的基因座。结果印度旁遮普妇女GDM患病率高于瑞典妇女，胰岛素分泌较低，胰岛素敏感性较好。GDM/T2 D危险等位基因在两个人群中的频率差异有统计学意义。rs7178572在HMG 20 A，以前与GDM在南印度和欧洲的妇女，是复制在北印度妇女。在斯堪的纳维亚人中，T2 D风险SNP rs 11605924与GDM风险增加相关，但在旁遮普印度妇女中与GDM风险降低相关。两个群体中GDM基因座之间没有其他重叠。结论印度女性糖尿病比瑞典女性更常见，这部分归因于胰岛素分泌和作用的差异。有显着的异质性GDM表型之间的人口，只能部分地解释了遗传差异。
Objective Gestational diabetes mellitus (GDM) is a transient form of diabetes characterized by impaired insulin secretion and action during pregnancy. Population-based differences in prevalence exist which could be explained by phenotypic and genetic differences. The aim of this study was to examine these differences in pregnant women from Punjab, India and Scandinavia. Methods Eighty-five GDM/T2D loci in European and/or Indian populations from previous studies were assessed for association with GDM based on Swedish GDM criteria in 4018 Punjabi Indian and 507 Swedish pregnant women. Selected loci were replicated in Scandinavian cohorts, Radiel (N = 398, Finnish) and STORK/STORK-G (N = 780, Norwegian). Results Punjabi Indian women had higher GDM prevalence, lower insulin secretion and better insulin sensitivity than Swedish women. There were significant frequency differences of GDM/T2D risk alleles between both populations. rs7178572 at HMG20A, previously associated with GDM in South Indian and European women, was replicated in North Indian women. The T2D risk SNP rs11605924 in the CRY2 gene was associated with increased GDM risk in Scandinavian but decreased GDM risk in Punjabi Indian women. No other overlap was seen between GDM loci in both populations. Conclusions Gestational diabetes mellitus is more common in Indian than Swedish women, which partially can be attributed to differences in insulin secretion and action. There was marked heterogeneity in the GDM phenotypes between the populations which could only partially be explained by genetic differences.