Signaling and functions of interleukin-33 in immune regulation and diseases.
Signaling and functions of interleukin-33 in immune regulation and diseases.
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DOI：
10.1016/j.cellin.2022.100042
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发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
Li, Shu
中科院分区：
文献类型：
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作者：
Yi, Xue-Mei;Lian, Huan;Li, Shu
白细胞介素-33（IL-33）属于白细胞介素-1（IL-1）家族，是一种报警细胞因子，在组织稳态、病原性感染、炎症、变态反应和2型免疫中起重要作用。IL-33通过其受体IL-33 R（也称为ST 2）传递信号，所述受体IL-33 R在辅助性T 2（Th 2）细胞和第2组先天性淋巴样细胞（ILC 2）的表面上表达，从而诱导Th 2相关细胞因子基因的转录和宿主对病原体的防御。此外，IL-33/IL-33 R轴还参与多种类型的免疫相关疾病的发展。本文就IL-33/IL-33 R轴在健康和疾病中的重要作用及其治疗意义作一综述。
Interleukin-33 (IL-33) which belongs to the interleukin-1 (IL-1) family is an alarmin cytokine with critical roles in tissue homeostasis, pathogenic infection, inflammation, allergy and type 2 immunity. IL-33 transmits signals through its receptor IL-33R (also called ST2) which is expressed on the surface of T helper 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s), thus inducing transcription of Th2-associated cytokine genes and host defense against pathogens. Moreover, the IL-33/IL-33R axis is also involved in development of multiple types of immune-related diseases. In this review, we focus on current progress on IL-33-trigggered signaling events, the important functions of IL-33/IL-33R axis in health and diseases as well as the promising therapeutic implications of these findings.