Ovarian Cancer Update Lessons From Morphology, Molecules, and Mice
Ovarian Cancer Update Lessons From Morphology, Molecules, and Mice
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DOI：
10.1043/1543-2165-133.11.1775
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发表时间：
2009-11-01
影响因子：
4.6
通讯作者：
Cho, Kathleen R.
中科院分区：
文献类型：
--
作者：
Cho, Kathleen R.
卵巢癌是一组异质性肿瘤。病理学家目前采用基于形态学的分类系统，根据程度（肿瘤分级）和分化类型（如浆液性、类浆液性、透明细胞性或粘液性）将卵巢癌分为主要亚组。分子研究表明，特定的遗传缺陷可能存在于某些组织学类型的卵巢癌中，而不太可能存在于其他类型的卵巢癌中。在浆液性癌和类浆液性癌中，低级别与高级别肿瘤的分子缺陷似乎也很大程度上不同。最近，已经开发了卵巢癌小鼠模型，该模型概括了卵巢癌的许多选定亚型的形态学特征和生物学行为。预计这些小鼠模型将对卵巢癌发病机制产生新的见解，并证明可用于卵巢癌治疗新策略的临床前测试。(Arch Pathol Lab Med. 2009; 133：1775-1781）
Ovarian carcinomas are a heterogeneous group of neoplasms. Pathologists currently employ a morphology-based classification system to divide ovarian carcinomas into major subgroups based on degree (tumor grade) and type of differentiation (eg, serous, endometrioid, clear cell, or mucinous). Molecular studies have shown that specific genetic defects are likely to be present in certain histologic types of ovarian carcinomas and unlikely to be present in others. Within the serous and endometrioid carcinomas, the molecular defects in low-grade versus high-grade tumors also appear to be largely distinct. Recently, mouse models of ovarian carcinoma have been developed that recapitulate many of the morphologic features and biologic behavior of selected subtypes of ovarian cancer. It is expected that these mouse models will yield new insights into ovarian cancer pathogenesis and prove useful for preclinical testing of novel strategies for ovarian cancer treatment. (Arch Pathol Lab Med. 2009; 133: 1775-1781)