Minimal arecaidine concentrations showing a promotion effect during DMBA induced hamster cheek pouch carcinogenesis
Minimal arecaidine concentrations showing a promotion effect during DMBA induced hamster cheek pouch carcinogenesis
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DOI：
10.1111/j.1600-0714.1996.tb00194.x
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发表时间：
1996-02-01
影响因子：
3.3
通讯作者：
Huang, YL
中科院分区：
文献类型：
--
作者：
Lin, LM;Chen, YK;Huang, YL
本研究的目的是确定最低槟榔碱浓度显示出对DMBA诱导的仓鼠颊囊癌变的协同作用。将112只雄性成年叙利亚金仓鼠分为16组，每组7只。在DMBA启动8周后，再用槟榔碱促进4周，当槟榔碱浓度为400 μ g/ml和500 μ g/ml时，肿瘤发生率为100%，平均肿瘤数分别为1.86 ± 0.63和1.86 ± 0.93（P
The purpose of the present study was to determine the minimal arecaidine concentrations showing a synergistic effect on DMBA-induced hamster cheek pouch carcinogenesis. One hundred and twelve male adult Syrian golden hamsters were divided into 16 groups, each containing seven animals. After eight weeks of DMBA initiation and then four weeks of arecaidine promotion, 100% tumor incidence was found with arecaidine concentrations of 400 mu g/ml and 500 mu/ml; average tumor numbers were 1.86+/-0.63 and 1.86+/-0.93 respectively (P