Acute, but not repeated, cocaine administration decreases renin secretion in the conscious male rat.
Acute, but not repeated, cocaine administration decreases renin secretion in the conscious male rat.
复制标题
急性但不重复的可卡因给药会减少清醒雄性大鼠的肾素分泌。
DOI：
10.1016/0304-3940(91)90789-v
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
VandeKar,LD
中科院分区：
文献类型：
--
作者：
Lakoski,JM;Rittenhouse,PA;Bonadonna,AM;VandeKar,LD
The effects of cocaine on renin secretion have been addressed and a previously unreported inhibitory effect has been identified on this neuroendocrine system in the conscious male rat. Acute intraperitoneal administration of cocaine dose-dependently (1.5, 7.5, 15, and 30 mg/kg; at 15 min) produced a significant decrease in both plasma renin activity (PRA) and plasma renin concentration (PRC). The time course of inhibition by cocaine in PRA and PRC revealed maximal effect at 15 min following a 15 mg/kg dose. In contrast, the long term administration of cocaine for 1, 7, or 30 days (15 mg/kg, twice daily, i.p.) did not produce changes in PRC.
