A competitive marathon race decreases neutrophil functions in athletes
A competitive marathon race decreases neutrophil functions in athletes
复制标题
DOI：
10.1002/bio.744
复制
发表时间：
2003-11-01
期刊：
影响因子：
2.9
通讯作者：
Sugawara, K
中科院分区：
文献类型：
--
作者：
Chinda, D;Nakaji, S;Sugawara, K
全程马拉松是正式径赛项目中最长的跑步比赛，是一种剧烈运动。然而，没有研究检查急性中性粒细胞功能的反应，竞争性马拉松比赛。本研究以36名刚完成第50届别府-大分每日马拉松42.195 km赛程的男性运动员为研究对象。在马拉松前后立即通过流式细胞术测量神经元氧化爆发活性、吞噬活性以及每个细胞的CD 11 b和CD 16表达。总白细胞/中性粒细胞计数显著增加（p < 0.001），而每个中性粒细胞的总氧化爆发活性在比赛后显著降低（p < 0.001）。此外，每个中性粒细胞的总吞噬活性在比赛后也有所下降，但不显著（p = 0.08）。虽然每个细胞的CD 11b表达没有变化，但每个细胞的CD 16表达在比赛后显著降低（p < 0.001）。总之，竞争性马拉松比赛降低了中性粒细胞功能（氧化爆发活性和吞噬活性），这可能部分是由于CD 16表达的降低。总中性粒细胞计数的增加可能反映了抵消中性粒细胞功能降低的代偿反应。版权所有（C）2003约翰威利父子有限公司。
A full marathon is the longest running race in official track events and is a form of acute exercise. However, no studies have examined the acute neutrophil function response to a competitive marathon race. Thirty-six male athletes who had just completed the 42.195 km course of the 50th Beppu-Oita Mainichi Marathon were enrolled in this study. Neutrophil oxidative burst activity, phagocytic activity and expression of CD11b and CD16 per cell were measured by flow cytometry immediately before and after the marathon. Total leukocyte/neutrophil counts increased significantly (p < 0.001), whereas total oxidative burst activity per neutrophil cell decreased significantly after the race (p < 0.001). Furthermore, total phagocytic activity per neutrophil cell also decreased after the race, although it was not significant (p = 0.08). Although CD11b expression per cell did not change, the expression of CD16 per cell significantly decreased (p < 0.001) after the race. In conclusion, a competitive marathon race decreased neutrophil functions (oxidative burst activity and phagocytic activity), which may be partly due to a decrease in CD16 expression. The increase in total neutrophil counts might reflect a compensatory response to counteract the decrease in neutrophil functions. Copyright (C) 2003 John Wiley Sons, Ltd.