Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s
Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s
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肝脏驻留 NK 细胞和粘膜 ILC1 的差异表型和功能特性
DOI：
10.1016/j.jaut.2015.09.004
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发表时间：
2016-02-01
影响因子：
12.8
通讯作者：
Tian, Zhigang
中科院分区：
文献类型：
--
作者：
Tang, Ling;Peng, Hui;Tian, Zhigang
第1组先天性淋巴样细胞（ILC）由常规自然杀伤（cNK）细胞、组织驻留NK细胞和粘膜ILC 1组成。最近发现的肝脏驻留NK细胞，它可以安装接触超敏反应，和粘膜ILC1，参与结肠炎的发病机制是不同的cNK细胞在几个方面，但他们如何相互关联的问题还没有明确澄清。在这里，我们表明，肝脏居民NK细胞和粘膜ILC1有不同的表型，证明了不同的表达模式的归巢相关分子。此外，粘膜ILC1表现出类似于肝脏驻留NK细胞的组织驻留。重要的是，肝脏驻留NK细胞表达相对高水平的细胞毒性效应分子，这是由粘膜ILC1表达差，并表现出更强的细胞毒性活性相比，粘膜ILC1。这些结果表明，不同的表型和功能特性的肝脏居民的NK细胞和粘膜ILC1，脱落的ILC家族的多样性的新的光。(C)2015爱思唯尔有限公司版权所有。
Group 1 innate lymphoid cells (ILCs) consist of conventional natural killer (cNK) cells, tissue-resident NK cells and mucosal ILC1s. Recently identified liver-resident NK cells, which can mount contact hypersensitivity responses, and mucosal ILC1s that are involved in pathogenesis of colitis are distinct from cNK cells in several aspects, but the issue of how they are related to each other has not been clearly clarified. Here, we show that liver-resident NK cells and mucosal ILC1s have different phenotypes, as evidenced by distinct expression patterns of homing-associated molecules. Moreover, mucosal ILC1s exhibit tissue residency akin to liver-resident NK cells. Importantly, liver-resident NK cells express relative high levels of cytotoxic effector molecules, which are poorly expressed by mucosal ILC1s, and exhibit stronger cytotoxic activity compared with mucosal ILC1s. These results demonstrate differential phenotypic and functional characteristics of liver-resident NK cells and mucosal ILC1s, shedding new light on the diversity of ILC family. (C) 2015 Elsevier Ltd. All rights reserved.