BONE-MINERAL CONTENT OF AMENORRHEIC AND EUMENORRHEIC ATHLETES
BONE-MINERAL CONTENT OF AMENORRHEIC AND EUMENORRHEIC ATHLETES
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DOI：
10.1056/nejm198408023110501
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发表时间：
1984-01-01
影响因子：
158.5
通讯作者：
SOUTHWORTH, MB
中科院分区：
文献类型：
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作者：
DRINKWATER, BL;NILSON, K;SOUTHWORTH, MB
研究了14名闭经运动员的低雌激素状态是否与其14名同龄人的局部骨量减少有关。两组运动员的年龄、身高、体重、运动和训练方案相匹配。通过双光子和单光子吸收测定法测量腰椎（L1至L4）和桡骨2个部位的骨量。骨密度在羊水渗漏组（平均1.12 g/cm 2）显著低于羊水渗漏组（平均1.30 g/cm 2）。两个桡骨部位均无显著差异。放射免疫测定证实，在以7天间隔抽取的4个静脉样品中，在闭经妇女中具有较低的平均雌二醇浓度（闭经组，38、58 μ g/ml，月经不调组，106.99 pg/cm 2）和孕酮峰值（闭经组，1.25 ng/ml，月经不调组，12.75 ng/ml）。3天的饮食史显示，营养摄入量没有显着差异，包括钙补充剂和不补充。两组在体脂百分比、初潮年龄、运动参与年数、训练频率和持续时间方面相似，但每周跑步英里数不同（羊水过多组，41.8英里[67.3公里];羊水过多组，24.9英里[40.1公里]）。在女性运动员中观察到的闭经可能伴随着腰椎矿物质密度的降低。
Whether the hypoestrogenic status of 14 amenorrheic athletes was associated with a decrease in regional bone mass relative to that of 14 of their eumenorrheic peers was investigated. The 2 groups of athletes were matched for age, height, weight, sport, and training regimens. Bone mass was measured by dual-photon and single-photon absorptiometry at the lumbar vertebrae (L1 to L4) and at 2 sites on the radius. Vertebral mineral density was significantly lower in the amenorrheic group (mean, 1.12 g/cm2) than in the eumenorrheic group (mean, 1.30 g/cm2). There was no significant difference at either radial site. Radioimmunoassay confirmed a lower mean estradiol concentration (amenorrheic group, 38, 58 .mu.g/ml, eumenorrheic group, 106.99 pg/cm2) and progesterone peak (amenorrheic group, 1.25 ng/ml, eumenorrheic group, 12.75 ng/ml) in the amenorrheic women, in 4 venous samples drawn at seven-day intervals. A 3 day dietary history showed no significant differences in nutritional intake, including Ca with and without supplements. The 2 groups were similar in percentage of body fat, age at menarche, years of athletic participation, and frequency and duration of training but differed in number of miles run per week (amenorrheic group, 41.8 miles [67.3 km]; eumenorrheic group, 24.9 miles [40.1 km]). The amenorrhea that is observed in female athletes may be accompanied by a decrease in mineral density of the lumbar vertebrae.