Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.
Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.
复制标题
血浆脂质代谢物与胎龄相关，但与支气管肺发育不良无关。
DOI：
10.1111/j.1651-2227.2012.02694.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Welty,StephenE
中科院分区：
文献类型：
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作者：
Rogers,LynetteK;Young,ChristineM;Pennell,MichaelL;Tipple,TrentE;Leonhart,KarenL;Welty,StephenE
目的：探讨早产儿血浆脂质代谢产物水平与支气管肺发育不良（BPD）的关系。这些研究还验证了一个次要假设，即血浆脂质代谢物水平与孕龄相关。方法：在出生后72小时内登记出生<32周妊娠的婴儿。 结果：调整混杂因素后，血脂水平与BPD无相关性，但特定的脂质代谢产物水平与胎龄相关。结论：早产儿不成熟的脂质代谢途径可能参与BPD及其他疾病的发病机制。
Aim:To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age.Methods:Infants born <32 weeks’ gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC‐MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis.Results:Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age.Conclusion:Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.