Morphologic changes in the lung during the lifespan of Fischer 344 rats.
Morphologic changes in the lung during the lifespan of Fischer 344 rats.
复制标题
Fischer 344 大鼠一生中肺部的形态变化。
作者：
Kent E. Pinkerton;Brenda E. Barry;John J. O'Neil;James A. Raub;Philip C. Pratt;J. Crapo
肺结构和功能的定量研究在整个寿命的Fischer 344大鼠的形态和生理技术。研究了1周龄、6周龄、5月龄、14月龄和26月龄的雄性动物以及5月龄、14月龄和26月龄的雌性动物。在出生后的前5个月，所有肺泡组织室的体积、表面积和细胞数量均显著增加。从5至26个月的年龄，重塑上皮和间质室继续发生，而内皮室保持相对不变。在上皮细胞室中，II型细胞与I型细胞的比例随年龄的增加而降低。在间质室的体积增加了39%的男性和89%的女性，从5至26个月的年龄的非细胞成分的胎盘。6周、14个月和26个月时雄性动物肺容量的生理学测量结果显示肺活量（VC）和总肺活量（TLC）进行性增加。从1周龄到5月龄，雄性动物的肺弥散量（DLO2）增加，从5月龄到26月龄，两种性别动物的肺弥散量（DLO2）保持相对不变。
Pulmonary structure and function were quantitatively investigated over the lifespan of the Fischer 344 rat by morphometric and physiologic techniques. Male animals 1 week, 6 weeks, 5 months, 14 months, and 26 months of age and female animals 5 months, 14 months, and 26 months of age were studied. All alveolar tissue compartments demonstrated significant increases in volume, surface area, and cell number during the first 5 months of life. From 5 to 26 months of age, remodelling in the epithelial and interstitial compartments continued to take place while the endothelial compartment remained relatively unchanged. In the epithelial compartment the ratio of type II cells to type I cells lining the alveolar surface decreased as age increased. In the interstitial compartment the volume of the noncellular components of the interstitium increased by 39% in males and by 89% in females from 5 to 26 months of age. Physiologic measurements of lung volumes in males at 6 weeks, 14 months, and 26 months demonstrated progressive increases in vital capacity (VC) and total lung capacity (TLC). Morphometric pulmonary-diffusion capacity (DLO2) increased in males from 1 week to 5 months of age and remained relatively unchanged from 5 to 26 months of age in both sexes.