“Clusters” of CJD in Slovakia: The first laboratory evidence of scrapie
“Clusters” of CJD in Slovakia: The first laboratory evidence of scrapie
复制标题
斯洛伐克克雅氏病“集群”：第一个痒病实验室证据
DOI：
10.1007/bf00143133
复制
发表时间：
1991
影响因子：
13.6
通讯作者：
M. Tatara
中科院分区：
文献类型：
--
作者：
E. Mitrová;S. Hunčaga;G. Hocman;O. Nyitrayová;M. Tatara
1987年在斯洛伐克(Orava)观察到流行性克雅氏病的发生。寻找CID病灶的原因表明，遗传和环境风险在聚集的患者中是一致的。由于海绵状脑病可能通过口服传播(牛海绵状脑病)，因此Orava也考虑了CJD病例的人兽共患病来源的可能性。由于对斯洛伐克瘙痒病的发生缺乏了解，Orava的两个Valasky品种的羊群中出现了中枢神经系统疾病的迹象，因此对绵羊进行了检查。在一个羊群中，神经组织病理学检查显示，绵羊脑部病变具有瘙痒病的特征。这些动物的冰冻脑组织被用来检测瘙痒病相关纤维。在同一群中的两只动物身上发现了它们。这是捷克-斯洛伐克首次在实验室确认瘙痒病。强调了可能的流行病学和经济影响。
Epidemic-like occurrence of Creutzfeldt-Jakob disease was observed in 1987 in Slovakia (Orava). Search for the cause of CID focus indicated a concidence of genetic and environmental risks in clustering patients. Since Spongiform Encephalopathies might be transmitted orally, (Bovine Spongiform Encephalopathy), the possibility of zoonotic source of CJD cases in Orava was also considered. A deficient knowledge about the occurrence of scrapie in Slovakia stimulated an examination of sheep with signs of CNS disorders in two flocks of Valasky breed in Orava. In one flock, neurohistopathological examination revealed in sheep brains lesions characteristic for scrapie. Frozen brain tissue of these animals were used for the detection of scrapie associated fibrils. They were found in 2 animals from the same flock. This is the first laboratory confirmation of scrapie in Czecho-Slovakia. The possible epidemiological and economical implications are emphasized.