Genetic impact of both sex hormones in male-typical behaviors.
Genetic impact of both sex hormones in male-typical behaviors.
复制标题
两种性激素对男性典型行为的遗传影响。
DOI：
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发表时间：
2011
影响因子：
--
通讯作者：
S. Kato
中科院分区：
文献类型：
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作者：
Takahiro Matsumoto;Kazuki Inoue;Takashi Sato;S. Kato
雄激素在广泛的生物过程中起着关键作用。这些包括精子发生、生殖器官的发育和大脑功能。雄激素的大多数作用是由核雄激素受体（AR）介导的，它是一种配体诱导的转录因子。为了阐明AR在靶组织中的生理意义，我们使用Cre-loxP系统成功地破坏了X染色体上的AR。雄性AR-null突变（ARKO）小鼠表现出睾丸雌性化突变（Tfm）的典型异常，包括雌性外生殖器和睾丸萎缩[1]。他们还会发展为迟发性肥胖[2]伴糖皮质激素分泌过量[3]和骨生长受损伴高骨转换[4]。此外，AR在正常卵泡发生中的重要作用表明雄激素/AR信号在雌性bbb中也具有重要的生理意义。另一方面，ar介导的雄激素信号在脑男性化中的生理作用尚未确定。我们在这里描述了性激素信号在男性典型行为表达背后的大脑性别差异中的合作作用。
Androgens have a critical role in a wide range of biological processes. These include spermatogenesis, development of reproductive organs, and brain function. Most actions of androgens are mediated by the nuclear androgen receptor (AR), which acts as a ligand-inducible transcription factor. To elucidate physiological significance of AR in target tissues, we succeeded in disrupting the AR on the X chromosome using a Cre–loxP system. Male AR-null mutant (ARKO) mice exhibit abnormalities typical of testicular feminization mutants (Tfm), including female external genitalia with atrophic testis [1]. They also develop late-onset obesity [2] with glucocorticoid overproduction [3] and impaired bone growth coupled with high bone turnover [4]. Moreover, essential role of AR for normal folliculogenesis suggests that androgen/AR signaling is also physiologically important in females [5]. On the other hand, the physiological role of AR-mediated androgen signaling in brain masculinization has not been established. We describe here the cooperative role of sex hormones signaling in brain sex differences underlying the expression of male-typical behaviors.
DOI：
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发表时间：
2000
影响因子：
11.1
作者：
S. Ogawa
通讯作者：
S. Ogawa