A metabolic-transcriptional network links sleep and cellular energetics in the brain.
A metabolic-transcriptional network links sleep and cellular energetics in the brain.
复制标题
代谢转录网络将大脑中的睡眠和细胞能量联系起来。
DOI：
10.1007/s00424-011-1030-6
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Wisor,JonathanP
中科院分区：
文献类型：
--
作者：
Wisor,JonathanP
本文综述了细胞代谢状态、转录调控变化和睡眠之间的机制联系。睡眠不足与大脑中细胞代谢状态的变化有关。响应细胞代谢状态的代谢传感器调节生物钟转录网络。生物钟基因转录活性的改变影响睡眠/觉醒状态的变化。睡眠状态的变化逆转睡眠不足引起的细胞代谢状态的变化。因此，提出细胞代谢传感器对生物钟基因的调节是细胞代谢状态与睡眠之间联系的关键中间步骤。对这种调节关系的研究可能会在细胞水平上提供对睡眠功能的见解。
This review proposes a mechanistic link between cellular metabolic status, transcriptional regulatory changes and sleep. Sleep loss is associated with changes in cellular metabolic status in the brain. Metabolic sensors responsive to cellular metabolic status regulate the circadian clock transcriptional network. Modifications of the transcriptional activity of circadian clock genes affect sleep/wake state changes. Changes in sleep state reverse sleep loss-induced changes in cellular metabolic status. It is thus proposed that the regulation of circadian clock genes by cellular metabolic sensors is a critical intermediate step in the link between cellular metabolic status and sleep. Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level.