USE OF TELEMETRY TO RECORD BODY-TEMPERATURE AND ACTIVITY IN MICE

USE OF TELEMETRY TO RECORD BODY-TEMPERATURE AND ACTIVITY IN MICE
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DOI:
10.1016/0160-5402(89)90031-4
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发表时间:
1989-04-01
期刊:
JOURNAL OF PHARMACOLOGICAL METHODS
影响因子:
--
通讯作者:
BROCKWAY, B
BROCKWAY, B
中科院分区:
其他
文献类型:
--
作者:
CLEMENT, JG;MILLS, P;BROCKWAY, B

文献摘要

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A complete, commercially available, integrated telemetry and data aquisition system is described, which is used to record core temperature and activity in mice. The system is comprised of a telemetry transmitter (implanted in the peritoneal cavity), a receiver (placed underneath the cage) connected to a computer with software (Dataquest), which converts the transmitter signals directly into core temperature and activity. The information is stored on either a floppy diskette or a hard disk in the computer. The effects of anesthesia (sodium pentobarbital, halothane), handling, aggregation, restraint, a cholinergic agonist (oxotremorine) and an anticholinesterase agent, soman (pinacolyl methylphosphonofluoridate), on core temperature and activity were examined. The telemetry system for the recording of core temperature and activity provides a more accurate assessment of the temporal effects of various drugs and is more efficient and less labor intensive than the use of a rectal temperature probe.