Antimicrobial Therapies - Methods and Protocols
Antimicrobial Therapies - Methods and Protocols
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抗菌疗法 - 方法和方案
DOI：
10.1007/978-1-0716-1358-0_23
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Donnellan S
中科院分区：
文献类型：
--
作者：
Donnellan S
人类疾病结核病（TB）是单一传染性病原体导致死亡的主要原因。据估计，世界人口的四分之一受到潜伏感染。药物开发和筛选缓慢而昂贵。我们已经开发了一种生理相关的检测方法，用于在免疫细胞内筛选抗结核药物。本章将描述一种新开发的结核病临床前药物筛选试验，使用高内容成像和药代动力学/药效学模型。
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world’s population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells. This chapter will describe a newly developed preclinical drug screening assay for TB,using high-content imaging and pharmacokinetic/pharmacodynamic modeling.