Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy
Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy
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DOI：
10.1117/1.jbo.17.4.045001
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发表时间：
2012-04-01
影响因子：
3.5
通讯作者：
Li, Pai-Chi
中科院分区：
文献类型：
--
作者：
Wang, Yu-Hsin;Liao, Ai-Ho;Li, Pai-Chi
本研究探讨了一种光声/超声双模造影剂，包括将其应用范围从图像对比度增强扩展到基于部位特异性靶向的联合诊断和治疗。造影剂由包裹金纳米棒（AuMBs）的白蛋白壳微泡组成。这些直径从亚微米到几微米不等的充满气体的微泡不仅具有回声效果，而且可以作为药物传递载体。金纳米棒用于增强光声和光热信号的产生。微泡封装后，金纳米棒的光吸收峰被调谐到760 nm，并保持不变。本文首先描述了双模对比增强，并演示了双模对比增强在细胞靶向和激光诱导热疗法中的应用。光声成像可用于监测治疗过程中的温度升高。验证了AuMBs的靶向能力，在激光功率为980 mW的情况下，温度升高了26℃，显示了双模态药物联合诊断和治疗的潜力。有针对性的光或声介导递送也是可能的。(C) 2012年中国光学仪器工程师学会。(jbo.17.4.045001 DOI: 10.1117/1.)
This study investigates a photoacoustic/ultrasound dual-modality contrast agent, including extending its applications from image-contrast enhancement to combined diagnosis and therapy with site-specific targeting. The contrast agent comprises albumin-shelled microbubbles with encapsulated gold nanorods (AuMBs). The gas-filled microbubbles, whose diameters range from submicrometer to several micrometers, are not only echogenic but also can serve as drug-delivery vehicles. The gold nanorods are used to enhance the generation of both photoacoustic and photothermal signals. The optical absorption peak of the gold nanorods is tuned to 760 nm and is invariant after microbubble encapsulation. Dual-modality contrast enhancement is first described here, and the applications to cellular targeting and laser-induced thermotherapy in a phantom are demonstrated. Photoacoustic imaging can be used to monitor temperature increases during the treatment. The targeting capability of AuMBs was verified, and the temperature increased by 26 degrees C for a laser power of 980 mW, demonstrating the potential of combined diagnosis and therapy with the dual-modality agent. Targeted photo- or acoustic-mediated delivery is also possible. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.4.045001]