Vascularization in the primate visual cortex during development
Vascularization in the primate visual cortex during development
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DOI：
10.1093/cercor/12.2.199
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发表时间：
2002-02-01
期刊：
影响因子：
3.7
通讯作者：
Imbert, M
中科院分区：
文献类型：
--
作者：
Fonta, C;Imbert, M
我们研究了灵长类动物出生后发育过程中视觉皮层血管形成和神经元活动之间的关系。分析集中在 IVC 层上，该层显示了不同亚层（分别为 IVCalpha 和 IVCbeta）中大细胞和小细胞系统的成熟顺序模式。使用细胞色素氧化酶和内源性碱性磷酸酶组织化学在同一切片上分析狨猴（Callithrix jacchus）初级视觉皮层的皮层活动和血管密度的层状模式。在五只幼年动物和两只成年动物中进行了实验。我们发现 IVCα 层和 IVCbeta 层血管生成的时间模式不同。在出生后第一个月，IVCα 中的血管密度高于 IVCbeta 中的血管密度，并且与细胞色素氧化酶强度平行。在 2 个月大的动物中，IVCα 和 IVCbeta 的血管密度和细胞色素氧化酶活性相似。在成人中，IVCα 和 IVCbeta 的血管密度与出生后第一个月观察到的相反。血管直径并不能解释血管模式的这种演变。在讨论中，我们认为血管生成的这种发育时间进程可能与灵长类纹状皮层中大细胞和小细胞系统的突触发生要求不同有关。
We studied the relationship between vascularization and neuronal activity in the visual cortex during postnatal development in the primate. Analyses were focused on layer IVC that displays a sequential pattern of maturation for the magno- and parvocellular systems in separate sublayers, respectively IVCalpha and IVCbeta. Cytochrome oxidase and endogeneous alkaline phosphatase histochemistry was used to analyse, on the same sections, the laminar patterns of cortical activity and vessel density in the primary visual cortex of the marmoset (Callithrix jacchus). Experiments were carried out in five young and two adult animals. We showed that the temporal pattern of angiogenesis differs in layer IVCalpha and IVCbeta. During the first postnatal month, vessel density is higher in IVCalpha than in IVCbeta and runs parallel to cytochrome oxidase intensity. In 2-month-old animals, both vessel densities and cytochrome oxidase activity are similar in IVCalpha and IVCbeta. In adults, the vessel densities in IVCalpha and IVCbeta are the reverse of those observed during the first postnatal month. Vessel diameter does not account for this evolution in vascular patterns. In the discussion, we suggest that such a developmental time-course of angiogenesis might be linked to the synaptogenesis requirements that proceed differently for the magno- and parvocellular systems in the primate striate cortex.