Association between [18F]fluorodeoxyglucose uptake and postoperative histopathology, hormone receptor status, thymidine labelling index and p53 in primary breast cancer:: a preliminary observation
Association between [18F]fluorodeoxyglucose uptake and postoperative histopathology, hormone receptor status, thymidine labelling index and p53 in primary breast cancer:: a preliminary observation
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DOI：
10.1007/s002590050319
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发表时间：
1998-10-01
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影响因子：
--
通讯作者：
Bombardieri, E
中科院分区：
文献类型：
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作者：
Crippa, F;Seregni, E;Bombardieri, E
为了探讨正电子发射断层扫描（PET）与氟-18氟脱氧葡萄糖（FDG）在原发性乳腺癌预后评估中的可能作用，我们研究了86例T1-3（TNM分类），并将肿瘤FDG摄取（计算为标准摄取值（SUV））与术后组织病理学结果、肿瘤的类固醇激素受体状态，胸苷标记指数（LI）和p53的组织表达。浸润性导管癌（n = 68;中位SUV = 5.6）的SUV显著高于小叶癌（n = 18;中位SUV = 3.8），3级癌（n = 26;中位SUV = 6.2）显著高于1-2级癌（n = 60;中位SUV = 4.9）。此外，SUV是显着较高的p53高水平的癌（n = 12;中位数SUV = 9.5）比那些与低水平（n = 48;中位数SUV = 4.25）。相比之下，SUV和类固醇激素受体状态或肿瘤LI之间没有显着相关性。我们的数据表明，FDG摄取，表示为SUV，是与某些预后因素，乳腺癌，如组织病理学分级和p53的表达，这只能通过术后体外检查进行评估。因此，FDG-PET提供的信息在一定程度上与肿瘤生物学相关信息相关。这些数据的临床价值必须通过对一系列有足够随访的患者进行多变量分析，分析SUV与其他预后因素的独立性来证实。如果SUV被证实为一个独立的变量，FDG-PET可以承担一个重要的作用，在确定适当的治疗策略，原发性乳腺癌。
To investigate the possible role of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) in the prognostic evaluation of primary breast cancer, we studied 86 patients with T1-3 (TNM classification) breast tumours before surgery and compared the tumour FDG uptake, calculated as a standardized uptake value (SUV), with postoperative histopathological findings, steroid hormone receptor status of the tumour, thymidine labelling index (LI) and tissular expression of p53. SUV was significantly higher in infiltrating ductal carcinomas (n = 68; median SUV = 5.6) than in lobular ones (n = 18; median SUV = 3.8), and in grade 3 carcinomas (n = 26; median SUV = 6.2) than in grade 1-2 ones (n = 60; median SUV = 4.9). Moreover, SUV was significantly higher in carcinomas with high levels of p53 (n = 12; median SUV = 9.5) than in those with low levels (n = 48; median SUV = 4.25). By contrast, there was no significant correlation between SUV and the steroid hormone receptor status or LI of tumours. Our data demonstrate that FDG uptake, expressed as SUV, is associated with certain prognostic factors in breast cancer, such as histopathological grading and p53 expression, which can be assessed only by means of postoperative in vitro examinations. Hence, the information provided by FDG-PET is to some extent related to relevant information on tumour biology. The clinical value of these data will have to be confirmed by analysis of the independence of SUV from other prognostic factors by means of a multivariate analysis performed on a larger series of patients with adequate follow-up. If SUV is confirmed as an independent variable, FDG-PET could assume an important role in the determination of appropriate therapeutic strategies for primary breast cancer.