Sodium-23 NMR relaxation times in body fluids.
Sodium-23 NMR relaxation times in body fluids.
复制标题
体液中的钠 23 NMR 弛豫时间。
DOI：
10.1002/mrm.1910030613
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发表时间：
1986
影响因子：
3.3
通讯作者：
Navon,G
中科院分区：
文献类型：
--
作者：
Shinar,H;Navon,G
测量了人血清、血浆、脑脊液（CSF）和血浆蛋白溶液中的23 Na纵向和横向NMR弛豫时间。磁化强度衰减曲线无法分解为两个指数。在这种情况下，从测量的弛豫率提取定量信息的程序开发。根据游离Na+、与小分子结合的Na+以及与体液中各种蛋白质组分结合的Na+的不同贡献，分析了血清和血浆中23 Na的弛豫时间。虽然T1基本上是游离Na+在溶液中的粘度比盐溶液略高，但T2受与蛋白质结合的影响，其中血清白蛋白的贡献最大。结合小分子对T1和T2的影响可以忽略不计。在几种磁场强度下测量弛豫时间，得到Na+与血清白蛋白结合的转动相关时间为16 ± 6ns。血清和血浆中结合的Na+含量粗略估计为总钠的0.02%。脑脊液中的弛豫时间与NaCl溶液中的弛豫时间非常相似。出版社：Academic Press，Inc.
23Na longitudinal and transverse NMR relaxation times were measured in human serum, plasma, cerebrospinal fluid (CSF), and solutions of plasma proteins. The magnetization decay curves could not be resolved into two exponentials. A procedure to extract quantitative information from the measured relaxation rates in such a case was developed. The relaxation times of23Na in serum and plasma were analyzed in terms of the different contributions from free Na+, Na+bound to small molecules, and Na+bound to various protein fractions in these body fluids. WhileT1is essentially that of free Na+in a solution which is slightly more viscous than salt solution,T2is influenced by binding to proteins with the largest contribution from serum albumin. The effect of binding to small molecules onT1andT2is negligible. From measurements of the relaxation times at several magnetic field strengths a rotational correlation time of Na+bound to serum albumin of 16 ± 6 ns was obtained. The fraction of bound Na+in serum and plasma was roughly estimated as 0.02% of the total sodium. The relaxation times in cerebrospinal fluid are very similar to those of NaCl solution. © 1986 Academic Press, Inc.