Patients' willingness to participate in clinical trials and their views on aspects of cancer research: results of a prospective patient survey
Patients' willingness to participate in clinical trials and their views on aspects of cancer research: results of a prospective patient survey
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DOI：
10.1186/s13063-015-1105-3
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发表时间：
2016-01-09
期刊：
影响因子：
2.5
通讯作者：
Rao, Sheela
中科院分区：
文献类型：
--
作者：
Moorcraft, Sing Yu;Marriott, Cheryl;Rao, Sheela
背景：临床试验的招募可能具有挑战性，并且比预期的要慢。这一前瞻性的患者调查的目的是调查的比例接近的患者同意参加试验，他们的动机，试验参与和他们的意见方面的癌症research.Methods：患者已接触的参与任何临床试验中的胃肠道和淋巴瘤单位在皇家马斯登被邀请完成一份问卷。统计分析主要是描述性的，报告了百分比。单变量logistic回归分析用于确定患者特征和患者respons.Results之间的任何关联：从2013年8月至2014年7月，276例患者收到298份临床试验患者信息表，并被要求完成问卷。大多数患者（263例患者，88%）同意参加临床试验，263例患者中有249例（95%）完成了问卷调查。参与临床试验的决定受到多种因素的影响，患者表示最重要的原因是试验提供了最好的治疗方法，并且试验结果可以使其他人受益。在249名问卷调查的受访者中，78%的人会捐赠他们的组织用于遗传研究，75%的人会考虑参加需要研究性活检的研究，75%的人认为应该告知患者试验结果。接受姑息治疗的患者和接受多线治疗的患者更愿意考虑研究性活检。接近临床试验的研究药物产品的患者中，48- 50%的人希望了解更多关于研究药物/程序的信息。结论：大多数接近临床试验的患者同意参加一项或多项试验。患者参与试验的动机包括潜在的个人利益和利他主义的原因。很大比例的患者愿意捐献组织用于研究，并考虑进行重复活检的试验。大多数患者认为应告知参与者试验结果，还有一组患者希望获得更详细的试验信息。
Background: Recruitment to clinical trials can be challenging and slower than anticipated. This prospective patient survey aimed to investigate the proportion of patients approached about a trial who agree to participate, their motivations for trial participation and their views on aspects of cancer research.Methods: Patients who had been approached about participation in any clinical trials in the Gastrointestinal and Lymphoma Unit at the Royal Marsden were invited to complete a questionnaire. The statistical analysis is mainly descriptive, with percentages being reported. Univariate logistic regression analysis was used to determine any associations between patient characteristics and patient responses.Results: From August 2013-July 2014, 276 patients received 298 clinical trial patient information sheets and were asked to complete the questionnaire. The majority of patients (263 patients, 88 %) consented to a clinical trial and 249 of the 263 patients (95 %) completed the questionnaire. Multiple factors influenced decisions to participate in clinical trials, with patients stating that the most important reasons were that the trial offered the best treatment available and that the trial results could benefit others. Of the 249 questionnaire respondents, 78 % would donate their tissue for genetic research, 75 % would consider participating in studies requiring a research biopsy and 75 % felt that patients should be informed of trial results. Patients treated with palliative intent and those who had received multiple lines of treatment were more willing to consider research biopsies. Of the patients approached about a clinical trial of an investigational medicinal product, 48-50 % would have liked more information on the study drugs/procedures.Conclusion: The majority of patients approached about a clinical trial consented to one or more trials. Patients' motivations for trial participation included potential personal benefit and altruistic reasons. A high proportion of patients were willing to donate tissue for research and to consider trials involving repeat biopsies. The majority of patients feel that participants should be informed of trial results and there is a group of patients who would like more detailed trial information.