Comparative uterine gene expression analysis after dioxin and estradiol administration
Comparative uterine gene expression analysis after dioxin and estradiol administration
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DOI：
10.1677/jme.1.01529
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发表时间：
2004-12-01
影响因子：
3.5
通讯作者：
Iguchi, T
中科院分区：
文献类型：
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作者：
Watanabe, H;Suzuki, A;Iguchi, T
环境污染物2，3，7，8-四氯二苯并对二恶英（TCDD）对许多生物体产生不利影响。已知接触四氯二苯并对二恶英与发育异常、肝毒性和内分泌效应有关。据报道，除了雌激素活性外，它还具有抗雌激素活性。为了阐明TCDD在子宫中的影响，我们评估了TCDD和雌二醇给药后的基因表达模式。在10000个排列的基因中，只有少数基因同时受到雌二醇和TCDD的影响。虽然对雌激素有反应的基因亚组也被TCDD激活，但对TCDD的反应比对雌二醇的反应更有限。因此，根据我们对基因表达模式的分析，TCDD在子宫中具有部分和弱的雌激素活性。
The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) adversely affects many organisms. TCDD exposure is known to be associated with abnormal development, hepatotoxicity and endocrine effects. It has also been reported to have antiestrogenic activity in addition to estrogenic activity. In order to clarify the effects of TCDD in the uterus, we evaluated the patterns of gene expression after TCDD and estradiol administration. Of the 10 000 arrayed genes, only a few were affected by both estradiol and TCDD. Although the subset of genes that responded to estrogen was also activated by TCDD, the response to TCDD was more limited than that observed in response to estradiol. Therefore, according to our analysis of gene expression patterns, TCDD had partial and weak estrogenic activity in the uterus.