Cannabis use and gastrointestinal tract illnesses: The National Health and Nutrition Examination Surveys, 2005-2018.
Cannabis use and gastrointestinal tract illnesses: The National Health and Nutrition Examination Surveys, 2005-2018.
复制标题
大麻使用和胃肠道疾病：2005-2018 年国家健康和营养检查调查。
DOI：
10.1111/dar.13609
复制
发表时间：
2023
影响因子：
3.8
通讯作者：
Alshaarawy,Omayma
中科院分区：
文献类型：
--
作者：
Vanderziel,Alyssa;Alshaarawy,Omayma
前言大麻的止吐特性促使其用于治疗化疗引起的恶心和呕吐。相反，大量吸食大麻者顽固性呕吐的案例报告越来越多地出现在文献中。关于大麻和胃肠道(GIT)健康的研究令人担忧。在这里，我们使用2005年至2018年全国健康和营养检查调查(NHANES)的数据来估计大麻使用与Git疾病之间的关联。方法研究样本包括未怀孕的成年NHANES参与者(20-59 岁)，没有癌症或艾滋病毒病史(n=18,753)。大麻的使用分为从不使用、以前使用(过去30 天中为0天)、不频繁使用(1-2 天)、偶尔使用(3-19 天)和频繁使用(20-30 天)。最近的GIT疾病被定义为在NHANES前30 开始出现呕吐或腹泻的GIT疾病。结果与从不吸食大麻相比，频繁吸食大麻与患胃肠疾病的几率较高(OR=1.40；95%可信区间1.04，1.9)。以前、不经常或偶尔使用大麻与胃肠道疾病之间没有关联。讨论和结论在一项针对美国居民的大型横断面研究中，频繁使用大麻与胃肠道疾病有关。与临床病例报告一致，频繁使用大麻可能会对胃肠道健康造成不利影响。或者，由于大麻的止吐特性，患有胃肠病的患者可能会自行用大麻服药。需要进行前瞻性研究，以了解大麻使用对胃肠道健康的影响。
IntroductionThe antiemetic properties of cannabis have motivated its use in the management of chemotherapy‐induced nausea and vomiting. Conversely, case reports of intractable vomiting among heavy cannabis users have increasingly appeared in the literature. Studies on cannabis and gastrointestinal tract (GIT) health are scare. Here, we use data for the National Health and Nutrition Examination Surveys (NHANES, 2005–2018) to estimate the association between cannabis use and GIT illness.MethodsThe study sample included non‐pregnant adult NHANES participants (20–59 years) without history of cancer or HIV (n= 18,753). Cannabis use was categorised into never, former (0 day in the past 30 days), infrequent (1–2 days), occasional (3–19 days) and frequent (20–30 days) use. Recent GIT illness was defined as experiencing GIT illness with vomiting or diarrhoea that started in the 30 days prior to NHANES. Logistic regression was used to regress GIT illness on cannabis use, adjusting for potential confounders.ResultsCompared to never use, frequent cannabis use was associated with higher odds of GIT illness (OR = 1.4; 95% confidence interval 1.04, 1.9). There were no associations between former, infrequent or occasional cannabis use and GIT illness.Discussion and ConclusionsFrequent cannabis use is associated with GIT illnesses in a large cross‐sectional study of US residents. It is possible that frequent cannabis use adversely affects GIT health, consistent with clinical case reports. Alternatively, patients with GIT illness might self‐medicate with cannabis given its antiemetic properties. Prospective studies are needed to understand the effects of cannabis use on GIT health.