Instructive effect of visual experience in mouse visual cortex
Instructive effect of visual experience in mouse visual cortex
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DOI：
10.1016/j.neuron.2006.06.026
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发表时间：
2006-08-03
期刊：
影响因子：
16.2
通讯作者：
Bear, Mark F.
中科院分区：
文献类型：
--
作者：
Frenkel, Mikhail Y.;Sawtell, Nathaniel B.;Bear, Mark F.
我们描述了清醒小鼠视觉皮层中一种依赖于经验的反应增强形式。重复呈现单一方向的光栅刺激会导致测试刺激引起的反应持续增强。反应增强是特定于测试刺激的方向的，在几次训练过程中逐渐发展，并且发生在幼年和成年小鼠中。刺激选择性反应增强（SRP）可以掩盖成年小鼠因剥夺而引起的反应抑制。 SRP 需要 NMDA 受体激活，并且可以通过病毒传递干扰 AMPA 受体运输的肽来阻止。 SRP 可能揭示某些形式的感知学习所涉及的机制。
We describe a form of experience-dependent response enhancement in the visual cortex of awake mice. Repeated presentations of grating stimuli of a single orientation result in a persistent enhancement of responses evoked by the test stimulus. Response potentiation is specific to the orientation of the test stimulus, develops gradually over the course of several training sessions, and occurs in both juvenile and adult mice. The stimulus-selective response potentiation (SRP) can mask deprivation-induced response depression in adult mice. SRP requires NMDA receptor activation and is prevented by viral delivery of a peptide that interferes with AMPA receptor trafficking. SRP may reveal the mechanisms involved in certain forms of perceptual learning.