The Efficacy of a Novel Tongue-Stabilizing Device on Polysomnographic Variables in Sleep-Disordered Breathing: A Pilot Study
The Efficacy of a Novel Tongue-Stabilizing Device on Polysomnographic Variables in Sleep-Disordered Breathing: A Pilot Study
复制标题
新型舌头稳定装置对睡眠呼吸障碍多导睡眠图变量的功效：初步研究
作者：
R. Kingshott;David R. Jones;D. Taylor;C. Robertson
在这项初步研究中，评估了一种新型稳舌装置(TSD)在治疗鼾症和睡眠障碍呼吸(SDB)中的多导睡眠图疗效。在随机交叉设计中，6名目前使用TSD和SDB的患者接受了多导睡眠监测，其中包括原位使用和不使用TSD的患者。每小时睡眠鼾声频率(61~70分贝范围)显著降低(无睡眠睡眠标准差：平均值=41次/小时睡眠±52标准差；标准睡眠标准差：8次/小时睡眠±16标准差；P=0.046)，但不改变其他分贝范围内的鼾声频率(均P&>0.1)。呼吸暂停加低呼吸频率减少(无TSD：26次/h睡眠±17次睡眠；TSD：15次/h睡眠±13次；P=0.06)；氧减饱和度4%或以上(无TSD：10次/h睡眠±10次；TSD：5次/h睡眠±5次；P=0.09)。治疗后患者的微觉醒频率明显改善(无睡眠障碍：34次/小时睡眠±16次；睡眠障碍：22次/小时睡眠±14次；P=0.004)。使用TSD的第一阶段睡眠百分比也显著降低(无TSD：10±3%；TSD：8±2%；P=0.03)。这项小型先导性研究的结果表明，TSD可能在降低鼾声严重程度和微唤醒方面有效，在选定的个体中具有降低SDB严重程度的有利趋势。还需要进行更大规模的前瞻性研究，以确定TSD用于治疗鼾症和SDB的合适候选者。
The polysomnographic efficacy of a novel tongue-stabilizing device (TSD) in the treatment of snoring and sleep-disordered breathing (SDB) was evaluated in this pilot study. Six current users of the TSD with SDB underwent polysomnography with and without the TSD in situ in a randomized crossover design. The TSD significantly lowered the frequency of snores per hour slept (61- to 70-dB range) (no TSD: mean = 41/h slept ± 52 SD; TSD: 8/h slept ± 16 SD; P = 0.046) but did not alter snoring in the other decibel ranges (all Ps > 0.1). Trends were found for reductions in the frequency of apneas plus hypopneas (no TSD: 26/h slept ± 17/h slept; TSD: 15/h slept ± 13; P = 0.06) and oxygen desaturations of 4% or more (no TSD: 10/h slept ± 10; TSD: 5/h slept ± 5; P = 0.09). Significant improvements in microarousal frequency with the TSD were found (no TSD: 34/h slept ± 16; TSD: 22/h slept ± 14; P = 0.004). Significant reductions in percentage of Stage 1 sleep with the TSD were also demonstrated (no TSD: 10 ± 3%; TSD: 8 ± 2%; P = 0.03). The results of this small pilot study indicate that the TSD may be effective in reducing snoring severity and microarousals, with favorable trends for reducing SDB severity in selected individuals. Additional larger prospective studies are required to identify suitable candidates for TSD use in the treatment of snoring and SDB.