Neocomplanines A and B, a Complanine Family Isolated from the Marine Fireworm
Neocomplanines A and B, a Complanine Family Isolated from the Marine Fireworm
复制标题
DOI：
10.1021/np900694j
复制
发表时间：
2010-03-01
影响因子：
5.1
通讯作者：
Uemura, Daisuke
中科院分区：
文献类型：
--
作者：
Nakamura, Kazuhiko;Tachikawa, Yu;Uemura, Daisuke
沙蚕碱家族的两个新成员，新沙蚕碱 A (2) 和 B (3)，作为“海洋火虫”Eurythoe complanata 甲醇提取物的次要成分被分离出来。通过光谱分析，新沙蚕素的结构被揭示为具有饱和碳链的三甲基铵单元。以环氧氯丙烷为起始原料，通过全合成成功证实了新沙蚕素A和B的平面结构。在体外存在 Ca(2+) 的情况下，新沙蚕素显示出炎症活性，并且与 TPA 结合可增强 PKC 活性；两者都与Complanine (1) 的作用相似。讨论了沙蚕碱相关化合物作用的分子机制。
Two new members of the complanine family, neocomplanines A (2) and B (3), were isolated as minor components of the methanolic extract of the "marine fireworm" Eurythoe complanata. The structures of the neocomplanines were revealed spectroscopically to be a trimethylammonium unit with a saturated carbon chain. The planar structures of neocomplanines A and B were confirmed successfully through total syntheses that used epichlorohydrin as a starting material. The neocomplanines show inflammatory activity and also enhanced PKC activity in combination with TPA in the presence of Ca(2+) in vitro; both arc similar to the effects of complanine (1). The molecular mechanism of the effects of complanine-related compounds is discussed.