Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?
Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?
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DOI：
10.1016/j.exger.2014.11.004
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发表时间：
2015-08
影响因子：
3.9
通讯作者：
Sell C
中科院分区：
文献类型：
--
作者：
Nacarelli T;Azar A;Sell C
在衰老相关的环境中，已经报道了通过核糖体S6磷酸化或核糖体S6激酶（p70 S6 K）活性测量的mTOR信号传导的意外激活。在老年小鼠和人类的心脏和肌肉组织、早衰症小鼠模型和衰老的人类成纤维细胞中已经报道了mTOR活性升高的证据。我们探讨了这些报告和mTOR/p70 S6 K激酶通路的激活可能代表ROS介导的对线粒体应激的反应，导致衰老的激活。这种激活是衰老组织和衰老人类细胞的标志。
Unexpected activation of mTOR signaling, measured by ribosomal S6 phosphorylation or ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related settings. Evidence of elevated mTOR activity has been reported in heart and muscle tissue in aged mice and humans, mouse models of progeria, and senescent human fibroblasts. We explore these reports and the possibility that activation of the mTOR/p70S6K kinase pathway may represent a ROS-mediated response to mitochondrial stress leading to the activation of senescence. This activation is a hallmark of both aged tissue and senescent human cells.