Bone healing at implants with a fluoride-modified surface: an experimental study in dogs
Bone healing at implants with a fluoride-modified surface: an experimental study in dogs
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DOI：
10.1111/j.1600-0501.2006.01309.x
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发表时间：
2007-04-01
影响因子：
4.3
通讯作者：
Lindhe, J.
中科院分区：
文献类型：
--
作者：
Berglundh, T.;Abrahamsson, I.;Lindhe, J.
目的：本实验的目的是研究早期阶段的骨整合种植体与氟化物改性surface.Material和方法：六个杂种狗，约1岁，被使用。拔除所有下颌前磨牙和下颌第一磨牙。三个月后，粘骨膜瓣在一侧的下颌骨和六个网站被确定为种植体放置。对照种植体（MicroThread（TM））具有TiOblast表面，而测试种植体（OsseoSpeed（TM））具有氟化物改性的TiOblast表面。两种类型的种植体具有相似的几何形状，直径为3.5 mm，长为8 mm。安装后，放置覆盖螺钉，调整皮瓣并缝合，以覆盖所有植入物。第一次种植手术后四周，在下颌骨的对侧重复安装程序。两周后，获得活组织检查并准备用于组织学分析。空隙之间发生的受体网站和种植体的宏线程立即种植体installation.Results的切割骨壁被用来研究早期骨形成：它被证明，在愈合的第一个2周内的空隙中形成的新骨的量是更大的氟化物改性的种植体（测试）比在TiOblast（对照）种植体。有人进一步观察到，骨种植体的接触，已建立后2周在宏螺纹部分的种植体的量显着大于在测试implants than at the controls.Conclusion：这表明，氟化物改性的种植体表面促进骨整合在早期阶段的愈合后种植体安装。
Objectives: The aim of the present experiment was to study early stages of osseointegration to implants with a fluoride-modified surface.Material and methods: Six mongrel dogs, about 1-year old, were used. All mandibular premolars and the first mandibular molars were extracted. Three months later, mucoperiosteal flaps were elevated in one side of the mandible and six sites were identified for implant placement. The control implants (MicroThread (TM)) had a TiOblast surface, while the test implants (OsseoSpeed (TM)) had a fluoride-modified TiOblast surface. Both types of implants had a similar geometry, a diameter of 3.5 mm and were 8 mm long. Following installation, cover screws were placed and the flaps were adjusted and sutured to cover all implants. Four weeks after the first implant surgery, the installation procedure was repeated in the opposite side of the mandible. Two weeks later, biopsies were obtained and prepared for histological analysis. The void that occurred between the cut bone wall of the recipient site and the macro-threads of the implant immediately following implant installation was used to study early bone formation.Results: It was demonstrated that the amount of new bone that formed in the voids within the first 2 weeks of healing was larger at fluoride-modified implants (test) than at TiOblast (control) implants. It was further observed that the amount of bone-to-implant contact that had been established after 2 weeks in the macro-threaded portion of the implant was significantly larger at the test implants than at the controls.Conclusion: It is suggested that the fluoride-modified implant surface promotes osseointegration in the early phase of healing following implant installation.