Overexpression of SCYL1 Is Associated with Progression of Breast Cancer.
Overexpression of SCYL1 Is Associated with Progression of Breast Cancer.
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SCYL1 的过度表达与乳腺癌的进展相关。
DOI：
10.3390/curroncol29100544
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发表时间：
2022-09-24
期刊：
影响因子：
2.6
通讯作者：
Lin, Qiong
中科院分区：
文献类型：
--
作者：
Sun, Aiqin;Tian, Xianyan;Yang, Wannian;Lin, Qiong
SCYL1是一种假激酶，在细胞分裂和基因转录、tRNA的核/胞质穿梭、蛋白质糖基化和高尔基体形态等方面发挥作用。然而，SCYL1在人类乳腺癌进展中的作用在很大程度上仍不清楚。在这项研究中，我们通过搜索癌症基因组图谱(TCGA)和肿瘤免疫分析资源(TIMER)数据库来确定SCYL1在乳腺癌中的表达。同时收集247例乳腺肿瘤组织标本，应用组织芯片技术(TMA)检测SCYL1在肿瘤组织中的表达。根据PrognoScan数据库确定SCYL1与乳腺癌预后的关系。结果表明，SCYL1在乳腺癌中过表达，且SCYL1的表达与乳腺癌患者的临床预后有关。此外，shRNAs对SCYL1基因的敲除显著抑制了乳腺癌细胞的增殖和迁移。综上所述，我们的数据提示SCYL1是乳腺癌预后不良的生物标志物，在乳腺癌进展中具有促进作用，是乳腺癌治疗的潜在靶点。
SCYL1 is a pseudokinase and plays roles in cell division and gene transcription, nuclear/cytoplasmic shuttling of tRNA, protein glycosylation, and Golgi morphology. However, the role of SCYL1 in human breast cancer progression remains largely unknown. In this study, we determined expression of SCYL1 in breast cancer by searching the Cancer Genome Atlas (TCGA) and Tumor Immunoassay Resource (TIMER) databases. Meanwhile, we collected breast tumor tissue samples from 247 cases and detected expression of SCYL1 in the tumors using the tissue microarray assay (TMA). Association of SCYL1 with prognosis of breast cancer was determined based on the PrognoScan database. The results have shown that SCYL1 is overexpressed in breast cancer, and the expression of SCYL1 is associated with poor clinical outcomes of breast cancer patients. Furthermore, knockdown of SCYL1 by shRNAs significantly inhibited the proliferation and migration of breast cancer cells. Taken together, our data suggest that SCYL1 is a biomarker for poor prognosis of breast cancer, has a promoting role in breast cancer progression, and is a potential target for breast cancer therapy.
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影响因子：
3.3
作者：
Chafe SC;Mangroo D
通讯作者：
Mangroo D
DOI：
10.1038/gim.2017.260
发表时间：
2018-10
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Lenz D;McClean P;Kansu A;Bonnen PE;Ranucci G;Thiel C;Straub BK;Harting I;Alhaddad B;Dimitrov B;Kotzaeridou U;Wenning D;Iorio R;Himes RW;Kuloğlu Z;Blakely EL;Taylor RW;Meitinger T;Kölker S;Prokisch H;Hoffmann GF;Haack TB;Staufner C
通讯作者：
Staufner C
影响因子：
3.7
作者：
Burman JL;Hamlin JN;McPherson PS
通讯作者：
McPherson PS
E3 泛素连接酶 NEDD4 介导肺癌细胞中 EGFR 的细胞迁移信号。
影响因子：
37.3
作者：
Shao G;Wang R;Sun A;Wei J;Peng K;Dai Q;Yang W;Lin Q
通讯作者：
Lin Q
影响因子：
50.3
作者：
Halberg N;Sengelaub CA;Navrazhina K;Molina H;Uryu K;Tavazoie SF
通讯作者：
Tavazoie SF