Standard atlas space for C57BL/6J neonatal mouse brain
Standard atlas space for C57BL/6J neonatal mouse brain
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DOI：
10.1007/s00429-005-0048-y
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发表时间：
2005-11-01
期刊：
影响因子：
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通讯作者：
Toga, AW
中科院分区：
文献类型：
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作者：
Lee, EF;Jacobs, RE;Toga, AW
以8个单独的共配MR图像体积的平均值为基础，构建了出生后0天（P0） C57BL/6J小鼠脑立体定位标准图谱空间。统计分析了配准的准确性和受试者之间的结构形态差异。我们还将该图谱坐标系统应用于使用不同成像方案获得的数据以及从不同动物获得的高分辨率组织学图谱。研究了地图集空间的映射精度，以确定该地图集框架的适用性。结果表明，本文定义的图谱空间为P0正常小鼠大脑图像配准提供了一个稳定的框架。通过适当的基于特征的协同配准策略，概率图谱还可以为侵入性成像方法获得的图像提供准确的解剖图谱。图谱模板和解剖标签的概率图可在http://www.loni.ucla.edu/MAP/上获得。
A standard atlas space with stereotaxic co-ordinates for the postnatal day 0 (P0) C57BL/6J mouse brain was constructed from the average of eight individual co-registered MR image volumes. Accuracy of registration and morphometric variations in structures between subjects were analyzed statistically. We also applied this atlas coordinate system to data acquired using different imaging protocols as well as to a high-resolution histological atlas obtained from separate animals. Mapping accuracy in the atlas space was examined to determine the applicability of this atlas framework. The results show that the atlas space defined here provides a stable framework for image registration for P0 normal mouse brains. With an appropriate feature-based co-registration strategy, the probability atlas can also provide an accurate anatomical map for images acquired using invasive imaging methods. The atlas templates and the probability map of the anatomical labels are available at http://www.loni.ucla.edu/MAP/.