The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma
The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma
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DOI：
10.1007/s10014-011-0062-0
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发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Fuller, Gregory N.
中科院分区：
文献类型：
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作者：
Li, Jian Yi;Langford, Lauren A.;Fuller, Gregory N.
血管中心性胶质瘤(AG)已被正式编入修订后的2007年WHO中枢神经系统肿瘤分类。AGS具有室管膜和弥漫性星形细胞分化混合特征，细胞增殖率低，Ki-67标记指数小于1%~5%。已报告1例间变性复发，标记指数为10%。在本研究中，我们报告了一系列的三个AGG(例1：4岁女孩在右额叶；例2：4岁男孩在左额叶；例3：9岁男孩在右颞叶)。例1表现为增殖指数升高(接近10%)，有丝分裂活性增强(每10个高倍视野有6个有丝分裂)，磷酸组蛋白H3(PHH3)免疫组化染色，然而，经过6年的随访，已经显示出长期的无复发生存。到目前为止，这是第一个用PHH3免疫染色评价AGs有丝分裂活性的报道。
Angiocentric glioma (AG) has been formally codified in the revised 2007 WHO Classification of Tumours of the Central Nervous System. AGs characteristically exhibit mixed features of ependymal and diffuse astrocytic differentiation and low proliferation rates, with Ki-67 labeling indices ranging from less than 1 to 5%. A single case with anaplastic recurrence and a labeling index of 10% has been reported. In the present study, we report a series of three AGs (Case 1: 4-year-old girl at right frontal lobe; Case 2: 4-year-old boy at left frontal lobe; Case 3: 9-year-old boy at right temporal lobe). Case 1 with elevated proliferation index (similar to 10%) and increased mitotic activity (six mitoses per 10 high-power fields) on phospho-histone H3 (pHH3) immunostain at presentation, nonetheless, has shown protracted recurrence-free survival after 6 years of follow-up. So far, this is the first report for evaluating the mitotic activity in AGs using pHH3 immunostain.