DIFFUSION OF SMALL NONELECTROLYTES ACROSS LIPOSOME MEMBRANES
DIFFUSION OF SMALL NONELECTROLYTES ACROSS LIPOSOME MEMBRANES
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DOI：
10.1038/236173a0
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发表时间：
1972-01-01
期刊：
影响因子：
64.8
通讯作者：
BANGHAM, AD
中科院分区：
文献类型：
--
作者：
COHEN, BE;BANGHAM, AD
Lieb和Stein1最近提出，生物膜在小分子量非电解质的扩散方面表现为均匀的聚合物网络（如橡胶）。鉴于越来越多的证据表明，大多数细胞或细胞器膜的实质性领域是由磷脂或其他脂质的双分子片，我们已经测试了使用模型系统的结构和组成，这是简单的和明确的假设。
Lieb and Stein1proposed recently that biological membranes behave as a homogeneous polymer network (such as rubber) with respect to the diffusion of small molecular weight non-electrolytes. In the light of accumulating evidence that substantial areas of most cell or cell organelle membranes are composed of a bimolecular sheet of phospholipids or other lipids, we have tested the hypothesis using a model system with structure and composition which are simple and well defined.