ROLE OF BLOOD-VOLUME EXPANSION IN DAHL RAT MODEL OF HYPERTENSION
ROLE OF BLOOD-VOLUME EXPANSION IN DAHL RAT MODEL OF HYPERTENSION
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DOI：
10.1152/ajpheart.1990.258.2.h508
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发表时间：
1990-02-01
影响因子：
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通讯作者：
COWLEY, AW
中科院分区：
文献类型：
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作者：
GREENE, AS;YU, ZY;COWLEY, AW
本实验采用连续测量和伺服控制的方法，研究了容积扩张在Dahl盐耐受（SR）和盐敏感（SS）大鼠高血压发生发展中的作用。钠摄入量从1至20 meq/天的变化与SS和SR大鼠96 h内总体重增加7.2%相关。SS（n = 10）和Sr（n = 10）大鼠的血浆钠（pNa）均从145.0增加至147.4 meq/l。仅在SS大鼠中，体积膨胀与动脉压增加27 ± 0.5%相关。3毫米汞柱。通过SC预防容量扩张阻断了SS大鼠（n = 10）的动脉压升高，但使pNa从143.5 meq/l增加至152.4 meq/l。两个非SC组的红细胞压积均从36.6%降至27.5%，但SC组的降幅较小（35.7%至32.0%）。血浆容量从17.6 . ±. 0.6至25.2 .+-。0.8在非SC大鼠、SS（n = 10）和SR（n = 9）大鼠中，盐摄入量的增加与心输出量从413 ± 0.5ml的增加有关。6到507 .+-. 12毫升min-1. kg-1。这些结果表明，需要液体潴留来触发Dahl SS大鼠的压力升高。
Continuous measurement and servo control (SC) of total body weight of unrestrained rats were used to investigate the role of volume expansion in the development of hypertension in Dahl salt-resistant (SR) and Dahl salt-sensitive (SS) rats. A change in sodium intake from 1 to 20 meq/day was associated with an increase in total body weight of 7.2% in both SS and SR rats over 96 h. Plasma sodium (pNa) increased from 145.0 to 147.4 meq/l in both SS (n = 10) and Sr (n = 10) rats. Only in the SS rats was the volume expansion associated with an increase in arterial pressure of 27 .+-. 3 mmHg. Prevention of the volume expansion by SC blocked the rise in arterial pressure in the SS rats (n = 10) but increased pNa from 143.5 to 152.4 meq/l. Hematocrit fell from 36.6 to 27.5% in both non-SC groups but decreased less in SC groups (35.7 to 32.0%). Plasma volume expansion from 17.6 .+-. 0.6 to 25.2 .+-. 0.8 ml in non-SC rats was greatly blunted by SC. In non-SC rats, SS (n = 10) and SR (n = 9) rats an increase in salt intake was associated with a rise in cardiac output from 413 .+-. 6 to 507 .+-. 12 ml .cntdot. min-1 .cntdot. kg-1 in both groups. These results indicate that fluid retention is required to trigger the rise of pressure in Dahl SS rats.