Prevalence of Autoimmune Gastritis in Individuals Undergoing Medical Checkups in Japan
Prevalence of Autoimmune Gastritis in Individuals Undergoing Medical Checkups in Japan
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DOI：
10.2169/internalmedicine.2292-18
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发表时间：
2019-01-01
影响因子：
1.2
通讯作者：
Kinoshita, Yoshikazu
中科院分区：
文献类型：
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作者：
Notsu, Takumi;Adachi, Kyoichi;Kinoshita, Yoshikazu
目的根据内镜检查结果和血清自身抗体水平，我们确定了日本健康体检者中自身免疫性胃炎（AIG）的患病率，该疾病以前未报道过。（4，288名男性，2，451名女性;平均年龄52.1岁）接受了上消化道内窥镜检查，作为年度体检的一部分。结果在6,739例受检者中，有46例根据内镜检查结果被怀疑为AIG，其中11例经胃镜检查证实为AIG，12例经胃镜检查证实为AIG，11例经胃镜检查证实为AIG。其中确诊33例，总患病率为0.49%（女性0.65%，男性0.40%）。七名AIG患者还患有甲状腺疾病，包括桥本氏病和巴塞杜病，而没有一例AIG患者在血液检查中显示贫血。两组间AIG的患病率无显著性差异。pylori感染状态（阴性、阳性、根除后）。结论在日本接受上消化道内镜检查作为年度体检的一部分的个体中，AIG的患病率为0.49%。我们的结论是，这是不罕见的无症状和健康的个人有AIG，并建议需要更多的研究，以澄清其患病率以及建立用于诊断的标准。
Objective Based on both endoscopic findings and serum auto-antibody levels, we determined the prevalence of autoimmune gastritis (AIG), which has not been previously reported, in individuals who underwent health checkup examinations in Japan.Methods At total of 6,739 subjects (4,288 males, 2,451 females; mean age 52.1 years) underwent an upper gastrointestinal endoscopic examination as part of an annual medical checkup. Those suspected to have AIG based on endoscopic evidence of proximal-predominant gastric mucosal atrophy were further examined for the presence of anti-parietal cells and anti-intrinsic factor antibodies, with a final diagnosis of AIG made in cases found to be positive for either or both of those factors.Results Of the 6,739 examined subjects, 46 were suspected to have AIG based on the endoscopic findings, of whom 33 were finally diagnosed with AIG, for an overall prevalence 0.49% (females 0.65%, males 0.40%). Seven with AIG also had thyroid disease, including Hashimoto's and Basedow disease, while none with AIG showed anemia in blood test findings. The prevalence of AIG was not different regardless of the H. pylori infection status (negative, positive, post-eradicated).Conclusion In individuals who underwent an upper gastrointestinal endoscopic examination as part of an annual checkup in Japan, the prevalence of AIG was 0.49%. We concluded that it is not uncommon for asymptomatic and healthy individuals to have AIG, and propose that additional studies are needed to clarify its prevalence as well as to establish the criteria used for diagnosis.