Sleep-promoting effects of muramyl peptides.
Sleep-promoting effects of muramyl peptides.
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胞壁酰肽的促进睡眠作用。
DOI：
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发表时间：
1982
影响因子：
11.1
通讯作者：
M. Karnovsky
中科院分区：
文献类型：
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作者：
J. Krueger;J. Pappenheimer;M. Karnovsky
最近从人尿中分离出一种胞壁酰肽，它能诱导大鼠、兔子和猫的过度慢波睡眠。我们现在报道合成的乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（“胞壁酰二肽”）及其赖氨酰衍生物（乙酰胞壁酰-L-丙氨酰-D-异谷氨酰赖氨酸）可以模拟天然肽的催眠作用。这两种化合物也有致热原性，并可能导致其他自主神经功能紊乱。静脉注射胞壁酰二肽的致热原作用可以通过先前的对乙酰氨基酚治疗来抑制，而不会阻断促进睡眠的作用。
A muramyl peptide that induces excess slow-wave sleep in rats, rabbits, and cats has recently been isolated from human urine. We now report that synthetic acetylmuramyl-L-alanyl-D-isoglutamine ("muramyl dipeptide") and its lysyl derivative (acetylmuramyl-L-alanyl-D-isoglutaminyllysine) can mimic the somnogenic effects of the natural peptide. Both compounds are also pyrogenic and may cause other disturbances of autonomic function. The pyrogenic effects of intravenously administered muramyl dipeptide can be suppressed by previous treatment with acetaminophen without blocking the sleep-promoting effects.