Multiexponential T-2 relaxation in degenerating peripheral nerve
Multiexponential T-2 relaxation in degenerating peripheral nerve
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DOI：
10.1002/mrm.1910350212
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发表时间：
1996-02-01
影响因子：
3.3
通讯作者：
Snyder, RE
中科院分区：
文献类型：
--
作者：
Does, MD;Snyder, RE
本文报道了在体和离体条件下，周围神经Wallerian变性的多指数T-2弛豫谱的测定。用挤压伤诱发了非洲爪蟾坐骨神经的变性，并在损伤后35天内多次测定了神经的T-2弛豫谱。组织学证据证实神经经历了沃勒变性。随着变性的进展，观察到松弛谱发生可测量的变化，最明显的是从三个良好分辨的T-2分量减少到一个，并且与最短T-2分量相关的谱分数下降。前者似乎反映了有髓纤维的塌陷和丢失，而后者是间质水肿和髓鞘丢失的组合。
The multiexponential T-2 relaxation spectrum of peripheral nerve undergoing Wallerian degeneration has been measured both in vivo and in vitro, Degeneration of the sciatic nerve of the amphibian Xenopus laevis was induced by crush injury, and T-2 relaxation spectra of the nerve were measured at several times up to 35 days following injury. Histologic evidence verified that the nerve underwent Wallerian degeneration, Relaxation spectra were observed to undergo measurable changes as degeneration progressed, the most evident being a reduction from three well-resolved T-2 components to one and a decline in the fraction of the spectra associated with the shortest T-2 component. The former appears to reflect the collapse and loss of myelinated fibers, while the latter a combination of interstitial edema and myelin loss.