Comparison of arterial stiffness indices measured by the Colins and SphygmoCor systems
Comparison of arterial stiffness indices measured by the Colins and SphygmoCor systems
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DOI：
10.1038/hr.2012.113
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发表时间：
2012-12-01
影响因子：
5.4
通讯作者：
Jang, Yangsoo
中科院分区：
文献类型：
--
作者：
Youn, Jong-Chan;Kim, Jong-Youn;Jang, Yangsoo
动脉僵硬是已知的心血管死亡率的独立预测因子。collins系统是一种简单易行的设备，已经得到了广泛的应用，但是对于高危中心动脉僵硬的临界值还没有很好的确定。我们研究了collins系统测量的动脉硬度与sphygmoor系统的常规测量之间的相关性。在948例高血压或冠状动脉疾病患者中，使用两种不同的设备在一次访问中测量动脉脉搏波速度（PWV）和增强指数（AIs）。sphygmoor和collins系统测量的PWV值之间存在很强的正相关。collins系统测量准确预测高危中心动脉硬度，定义为颈动脉-股动脉PWV >= 12 ms(-1)，在训练集（N = 664）中，受者-工作特征曲线下面积（AUC）为0.884（心脏-股动脉PWV， hfPWV）和0.830（肱-踝动脉PWV， baPWV）。截断值分别为11.18 ms（hfPWV）和16.17 ms(-1) (baPWV)，在验证集（N = 284）中具有良好的鉴别性，敏感性分别为83.3 ms（hfPWV）和76.0% (baPWV)，特异性分别为74.9 ms（hfPWV）和82.6% （baPWV）。sphygmoor和collins AI系统也表现出中度正相关。根据脉压>= 50 mmHg的定义，collins AI系统可以更好地预测高危中心脉压（AUC: collins, 0.765; sphygmoor, 0.692; P = 0.011）。collins系统测量的动脉刚度与sphygmoor系统测量结果具有较强的正相关和一致性。collins系统中高危中心动脉僵硬的临界值需要在前瞻性研究中进一步验证。高血压研究（2012）35,1180-1184；doi: 10.1038 / hr.2012.113;2012年7月26日在线发布
Arterial stiffness is a known independent predictor of cardiovascular mortality. The Colins system is an easy device and has gained widespread use, but the cutoff value for high-risk central arterial stiffness is not well established. We investigated the correlation between arterial stiffness measured by the Colins system with conventional measurements from the SphygmoCor system. Arterial pulse wave velocity (PWV) and augmentation indices (AIs) were measured on a single visit using two different devices in 948 patients with hypertension or coronary artery disease. Strong positive correlations were observed for PWV values measured by the SphygmoCor and Colins systems. The Colins system measurements accurately predicted high-risk central arterial stiffness, defined as carotid-femoral PWV >= 12 ms(-1), with an area under the receiver-operating characteristic curve (AUC) of 0.884 (heart-femoral PWV, hfPWV) and 0.830 (brachial-ankle PWV, baPWV) in the training set (N = 664). The cutoff values, 11.18 (hfPWV) and 16.17 ms(-1) (baPWV), showed good discrimination in the validation set (N = 284), with sensitivity of 83.3 (hfPWV) and 76.0% (baPWV), and specificity of 74.9 (hfPWV) and 82.6% (baPWV). The SphygmoCor and Colins AI systems also showed moderate positive correlation. The Colins AI system better predicted high-risk central pulse pressure as defined by pulse pressure >= 50 mmHg (AUC: Colins, 0.765; SphygmoCor, 0.692; P = 0.011). Arterial stiffness measured by the Colins system showed strong positive correlation and agreement with the SphygmoCor system measurement. Cutoff values for high-risk central arterial stiffness in the Colins system need further validation in a prospective study. Hypertension Research (2012) 35, 1180-1184; doi:10.1038/hr.2012.113; published online 26 July 2012