Translating batch electrochemistry to single-pass continuous flow conditions: an organic chemist's guide
Translating batch electrochemistry to single-pass continuous flow conditions: an organic chemist's guide
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DOI：
10.1007/s41981-019-00050-z
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发表时间：
2020-03-01
影响因子：
2.7
通讯作者：
Cantillo, David
中科院分区：
文献类型：
--
作者：
Maljuric, Snjezana;Jud, Wolfgang;Cantillo, David
最近有机合成电化学方法的复兴也引起了人们对流动电化学作为最合适的放大策略的兴趣的增加。许多使用流通池的电化学方法都是基于电解质溶液的再循环。然而，单程处理非常有吸引力，因为它允许将电化学反应与连续流中的其他合成或纯化步骤集成。对于该领域的初学者来说，将批量电化学程序转换为单程连续流通池可能具有挑战性。本文以4-甲基苯甲醚的电化学甲氧基化为模型，为该领域的新手概述了开发流动电化学过程需要考虑的因素，包括小规模反应中恒电流和恒电位模式操作的优缺点，以及极间间隙、支持电解质浓度和压力对反应性能的影响。还比较了间歇式和流动式的反应效率。
The recent renaissance of electrochemical methods for organic synthesis has also attracted increased interest towards flow electrochemistry as the most suitable scale-up strategy. Many electrochemical methods using flow cells are based on recirculation of the electrolyte solution. However, single-pass processing is very attractive as it permits integration of the electrochemical reaction with other synthetic or purification steps in a continuous stream. Translation of batch electrochemical procedures to single-pass continuous flow cells can be challenging to beginners in the field. Using the electrochemical methoxylation of 4-methylanisole as model, this paper provides newcomers to the field with an overview of the factors that need to be considered to develop a flow electrochemical process, including advantages and disadvantages of operating in galvanostatic and potentiostatic mode in small scale reactions, and the effect of the interelectrode gap, supporting electrolyte concentration and pressure on the reaction performance. A comparison of the reaction efficiency in batch and flow is also presented.