Mutual associations among microstructural, physical and mechanical properties of human cancellous bone
Mutual associations among microstructural, physical and mechanical properties of human cancellous bone
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DOI：
10.1302/0301-620x.84b6.11994
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发表时间：
2002-08-01
影响因子：
--
通讯作者：
Hvid, I
中科院分区：
文献类型：
--
作者：
Ding, M;Odgaard, A;Hvid, I
先前的研究表明，低密度的棒状小梁结构出现在低应力区域，而高密度的板状小梁结构出现在高应力区域。这一现象表明，小梁结构的类型与力学性能之间可能存在密切的关系。在本研究中，从40例年龄在16岁至85岁之间的正常人胫骨中提取160例松质骨标本。对试样进行显微ct扫描，并采用无偏三维方法计算其显微组织性能。对试样进行了力学性能测试，并对其物理/成分性能进行了评估。胫骨松质骨的结构类型和各向异性与杨氏模量具有良好的相关性。板状结构机械应力高，棒状结构机械应力低。骨小梁结构类型与骨体积分数之间有很强的相关性。预测松质骨力学特性最有效的微观结构特性似乎随年龄而不同。
Previous studies have shown that low-density, rod-like trabecular structures develop in regions of low stress, whereas high-density, plate-like trabecular structures are found in regions of high stress. This phenomenon suggests that there may be a close relationship between the type of trabecular structure and mechanical properties.In this study, 160 cancellous bone specimens were produced from 40 normal human tibiae aged from 16 to 85 years at post-mortem. The specimens underwent micro-CT and the microstructural properties were calculated using unbiased three-dimensional methods.The specimens were tested to determine the mechanical properties and the physical/compositional properties were evaluated. The type of structure together with anisotropy correlated well with Young's modulus of human tibial cancellous bone. The plate-like structure reflected high mechanical stress and the rod-like structure low mechanical stress. There was a strong correlation between the type of trabecular structure and the bone-volume fraction. The most effective microstructural properties for predicting the mechanical properties of cancellous bone seem to differ with age.